CAS: 54239-37-1; 2-Amino-5-[1-Hydroxy-2-(Propan-2-Ylamino)Ethyl]Benzonitrile

该化合物是一种合成化合物,被归类为乙型抗食性激动剂,主要以其在兽医学中使用,特别是牲畜中,以促进生长和提高饲料效率,它对乙型-2肾上腺受体有作用,导致肌肉质量增加,脂肪沉积减少;Cimaterol的特点是有能力加强蛋白合成和刺激脂解,使其对农业和研究环境都感兴趣;该化合物的施用通常是有控制的方式,以避免潜在的副作用,如心血管问题或代谢干扰;在化学结构方面,Cimaterol具有苯丙基氢氧基化合物组和有助于其生物活动的侧链的特点;虽然已经研究过它的潜在应用,但对其在食品生产动物中的使用的关切已导致各地区的监管检查;与许多乙型动物一样,Cimaterol的使用受到严格的监管,以确保食物安全和动物福利.

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CAS号33720-71-7 5-乙酰基-2-氨基苯腈 | CAS号56759-32-1 1-(4-氨基-3-溴-苯基)-乙酮 | CAS号99-92-3 4-氨基苯乙酮 | CAS号88167-50-4 2-amino-5-(2-br...

合成工艺路线路线简述

    📜4-氨基-3-氰基苯乙酮置于copper(Ll) Bromide体系中,用 四氢呋喃,乙醇,氯仿,乙酸乙酯 作为反应溶剂,化学反应 24.0H,反应生成 喜马特罗
    参考文献:苯乙醇胺类β受体激动剂的合成方法
    标题:苯乙醇胺类β受体激动剂的合成方法
    摘要:本发明公开了一种苯乙醇胺类β受体激动剂的合成方法,包括以下步骤:S1:将4‑氨基苯乙酮溶解在有机溶剂中,与亲电取代试剂发生苯环上的卤代反应,反应生成卤苯类中间体;卤苯类中间体在有机溶剂或水中,在金属催化剂的催化下与氰化试剂发生亲核取代反应,反应生成苯乙酮类中间体;s2:苯乙酮类中间体在有机溶剂中,与溴化铜发生羰基α溴代反应反应生成α‑溴代苯乙酮类中间体;s3:α‑溴代苯乙酮类中间体在有机溶剂中与叔丁胺或异丙胺反应反应生成苯乙酮胺类中间体;s4:苯乙酮胺类中间体在有机溶剂中,与还原氢化试剂反应反应生成苯乙醇胺类β受体激动剂;本发明合成方法简单高效且原料廉价易得,原子利用率较高,合成产物化学纯度大于99%,满足食品安全检测需求.

    海关参考信息

    专利信息


    专利号:US-9353057-B2
    优先权日:2003-12-30
    标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
    权利人:XENOPORT INC
    摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

    专利号:US-2015158809-A9
    优先权日:2013-02-26
    标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
    发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
    权利人:XENOPORT INC
    摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

    专利号:WO-2009094569-A2
    优先权日:2008-01-25
    标 题:Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates

    专利号:US-2005222431-A1
    优先权日:2003-12-30
    标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

    专利号:US-7227028-B2
    优先权日:2003-12-30
    标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

    专利号:US-2007244331-A1
    优先权日:2003-12-30
    标 题 :Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof

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    主要参考文献


    1: Kim YS, Sainz RD, Summers RJ, Molenaar P. Cimaterol reduces beta-adrenergic receptor density in rat skeletal muscles. J Anim Sci. 1992 Jan;70(1):115-22. Chinese. Erratum in: J Anim Sci 1988 May;66(5):1320. ^

    合成参考文献


    参考文献:10.1007/s00216-010-3484-3
    摘要:Peters RJB, Oosterink JE, Stolker AAM, Georgakopoulos C, Nielen MWF. Generic sample preparation combined with high-resolution liquid chromatography–time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. Analytical and Bioanalytical Chemistry. 2010 Feb 16;396(7):2583–98. doi: 10.1007/s00216-010-3484-3.
    参考文献:10.1186/1472-6750-10-12
    摘要:Zhong L, Zhang W, Zer C, Ge K, Gao X, Kernstine KH. Protein microarray: sensitive and effective immunodetection for drug residues. BMC Biotechnol. 2010 Feb 16;10():12.
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