1,2-二氨基环己烷,氯乙酸置于四甲基氢氧化铵,盐酸体系中,用 水 作为反应溶剂,化学反应 1.0H,反应生成 1,2-环己二胺四乙酸 参考文献:Preparation And Purification Of Hydroxylamine Stabilizers 标题:Preparation And Purification Of Hydroxylamine Stabilizers 摘要:本发明涉及制备超高纯度的1,2-二氨基环己烷四乙酸,其基本上不含有不需要的金属和金属离子污染物,并将其用作超高纯度羟胺化合物的稳定剂,该羟胺化合物广泛用于生产高级电子元件.
专利号:WO-2024199310-A1 优先权日:2023-03-31 标 题 :Method for enzymatic synthesis of capped mrna in one tube 发明人:LI YALI; ZHU HUAXING; ZHANG QINGYI 权利人:NOVOPROTEIN SCIENT INC 摘要:Provided is a method for enzymatic synthesis of capped mRNA in one tube. In the method, the step of purifying mRNA after IVT is omitted, and a capped product having a higher capping efficiency and fewer by-products is obtained. The method provided for enzymatic synthesis of capped mRNA is simple, convenient and short in terms of the process, and is rapid and efficient, so that the production process of a capped mRNA product is simplified, and a production cost is reduced, which is conducive to industrial production.
专利号:WO-9640901-A1 优先权日:1995-06-07 标题 :Template and primer based synthesis of enzymatically cleavable oligonucleotides 发明人:DATTAGUPTA NANIBHUSHAN; KACIAN DANIEL LOUIS; LACKEY DAVID BRUCE 权利人:GEN PROBE INC 摘要:The present invention relates to methods of enzymatically synthesizing chirally pure oligonucleotides. In particular, it relates to methods of enzymatically synthesizing oligonucleotides using optionally digestible templates which are capable of directing the synthesis of an oligonucleotide product which can optionally be cleaved into two or more individual oligonucleotides, optionally using 3'-ribonucleotide primers. In this manner, more than one oligonucleotide having the same or different length and/or sequence can be simultaneously synthesized. The oligonucleotides optionally have at least one phosphorothioate linkage, and contain certain restriction endonuclease recognition sites herein identified as cleavable within phosphorothioate oligonucleotides, thus facilitating the separation and purification of the oligonucleotides after synthesis.
专利号:US-6329543-B1 优先权日:1999-05-06 标题:Process for synthesis of isobornyl (Meth) acrylate 发明人:KNEBEL JOACHIM; SAAL DORIS 权利人:ROEHM GMBH 摘要:The present invention relates to processes for synthesis of isobornyl (meth)acrylate by reacting camphene with (meth)acrylic acid in the presence of sulfuric acid and at least one compound having inhibiting action. Aqueous sulfuric acid with an acid concentration in the range of 65 to 85 wt % is used. Isobornyl (meth)acrylate can advantageously be distilled from a mixture containing sulfuric acid in the presence of 2,6-di-tert-butyl-alpha-(dialkylamino)-p-cresol.
专利号:US-12018313-B2 优先权日:2016-12-28 标题:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles 发明人:EMBREE MALLORY 权利人:NATIVE MICROBIALS INC 摘要:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles, including dosed microbial ensembles and inoculative microbial ensembles, are disclosed.
专利号:US-7070757-B2 优先权日:2000-10-02 标 题:Method for producing catalysts consisting of metal of the platinum group by means of electroless deposition and the use thereof for the direct synthesis of hydrogen peroxide 发明人:FISCHER MARTIN; BUTZ THOMAS 权利人:BASF AG 摘要:Catalysts produced by electroless deposition of at least one platinum metal on a nonporous nonmetallic support can be used for the synthesis of hydrogen peroxide from the elements and for the hydrogenation of organic compounds.
专利号:US-5916777-A 优先权日:1995-06-07 标 题:Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers 发明人:KACIAN DANIEL LOUIS; DATTAGUPTA NANIBHUSHAN; LACKEY DAVID BRUCE 权利人:GEN PROBE INC 摘要:The present invention relates to methods of enzymatically synthesizing oligonucleotides. In particular, it relates to the use of 3'-ribonucleotide primers which effectively serve to initiate oligonucleotide synthesis, and can also be easily cleaved from synthesis products and reused in subsequent synthesis reactions.
1: Xie J, Funakoshi T, Shimada H, Kojima S. Effects of chelating agents on testicular toxicity in mice caused by acute exposure to nickel. Toxicology. 1995 Dec 10;103(3):147-55. doi: 10.1007/BF00393913. Epub 2004 Sep 29. 7: Xie J, Funakoshi T, Shimada H, Kojima S. Effects of chelating agents on tissue distribution and excretion of nickel in mice. Res Commun Mol Pathol Pharmacol. 1994 Nov;86(2):245-55. doi: 10.1186/s13568-018-0633-0.
合成参考文献
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