CAS: 42166-50-7; Pyridin-3-Ylhydrazine

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364727-74-2 650638-17-8 1289121-90-9

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CAS号29983-17-3 Hydrazinecarbot... | CAS号24334-19-8 1H-吡咯并[2,3-c]吡啶... | CAS号24334-20-1 1H-吡咯并[2,3-C]吡啶-2-羧酸 | CAS号650638-16-7 5-氨基-1-(3-吡啶)-1... | CAS号650638-18-9 1,5-二氢-1-(3-吡啶)... | CAS号650638-19-0 4-氯-1-(3-吡啶)-1H...

📜3-羟基吡啶置于一水合肼体系中,化学反应 10.0H,反应生成 3-肼基吡啶
参考文献:A Novel Potent Metal-Binding Ndm-1 Inhibitor Was Identified By Fragment Virtual,Spr And NMR Screening
标题:A Novel Potent Metal-Binding Ndm-1 Inhibitor Was Identified By Fragment Virtual,Spr And NMR Screening
摘要:Ndm-1 Can Hydrolyze Nearly All Available β-Lactam Antibiotics,Including Carbapenems. Ndm-1 Producing Bacterial Strains Are Worldwide Threats. It Is Still Very Challenging To Find A Potent Ndm-1 Inhibitor For Clinical Use. In Our Study,We Used A Metal-Binding Pharmacophore (Mbp) Enriched Virtual Fragment Library To Screen Ndm-1 Hits. Spr Screening Helped To Verify The Mbp Virtual Hits And Identified A New Ndm-1 Binder And Weak Inhibitor A1. A Solution NMR Study Of 15N-Labeled Ndm-1 Showed That A1 Disturbed All Three Residues Coordinating The Second Zinc Ion (Zn2) In The Active Pocket Of Ndm-1. The Perturbation Only Happened In The Presence Of Zinc Ion,Indicating That A1 Bound To Zn2. Based On The Scaffold Of A1,We Designed And Synthesized A Series Of Ndm-1 Inhibitors. Several Compounds Showed Synergistic Antibacterial Activity With Meropenem Against Ndm-1 Producing K. Pneumoniae.
DOI:10.1016/j.Bmc.2020.115437

专利信息

专利号:US-4093812-A
优先权日:1975-03-25
标 题:(Nitrofuryl)pyrazoles, their synthesis and use, and compositions containing them
发明人：RAINER GEORG
权利人:BYK GULDEN LOMBERG CHEM FAB
摘要:3-(5-Nitro-2-furyl)pyrazoles unsubstituted in the 5-position and 5-(5-nitro-2-furyl)pyrazoles unsubstituted in the 3-position are antimicrobials and disinfectants. The compounds are structurally represented by one of the formulae: ##STR1## wherein A is --CHO, --CN, --COOH, a protected or derived aldehyde group or a protected or derived carboxylic acid group; n B is 5-nitro-2-furyl; n R 1 is --H, substituted or unsubstituted hydrocarbyl (saturated or unsaturated; acyclic, alicyclic or aromatic; or araliphatic); substituted or unsubstituted (cycloaliphatic or aromatic) heterocyclic or acyl (carboxylic or carbonic acid); n R 2 is --H; and n n is a positive whole number of at most 2.

专利号:US-9714226-B2
优先权日:2011-07-29
标题:Hydrazide containing nuclear transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT P; SHACHAM SHARON; MCCAULEY DILARA; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: n nor a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.