专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:CN-114181139-B 优先权日:2021-12-27 标题:A kind of synthesis method of 5-halogenated nicotinic acid
专利号:US-RE47415-E 优先权日:2009-02-17 标题:Pyrimidinecarboxamides as CXCR2 modulators 发明人:MAEDA DEAN Y; ZEBALA JOHN A 权利人:SYNTRIX BIOSYSTEMS INC 摘要:There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.
专利号:CN-116947747-A 优先权日:2023-06-28 标 题 :A kind of synthesis technology of 2,3-dichloro-5-trifluoromethylpyridine
专利号:US-7361671-B2 优先权日:2001-11-15 标 题 :Substituted heteroarylalkanoic acids 发明人:VAN ZANDT MICHAEL C; GERACI LEO 权利人:INST PHARMACEUTICAL DISCOVERY 摘要:Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)R′, where D, A, and R′ are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.