CAS: 4111-54-0; Lithium,Di(Propan-2-yl)Azanide

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CAS号108-89-4 4-甲基吡啶 | CAS号60-29-7 乙醚 | CAS号116332-54-8 N-甲基-N-甲氧基-4-氟苯甲酰胺 | CAS号7087-68-5 N,N-二异丙基乙胺 | CAS号108-18-9 二异丙胺 | CAS号109-72-8 正丁基锂 | CAS号540-88-5 醋酸叔丁酯 | CAS号124-13-0 正辛醛 | CAS号849585-22-4 2-羟基丙酸 | CAS号75-31-0 异丙胺 | CAS号1120-87-2 4-溴吡啶 | CAS号10168-00-0 4-溴-3-甲基吡啶 | CAS号3430-22-6 4-甲基-3-溴吡啶 | CAS号4107-98-6 N,N-二异丙苯胺 | CAS号34636-09-4 苄基二异丙基胺 | CAS号446-22-0 2-氟苯丙酮 | CAS号21673-26-7 (N,N-dimethylam... | CAS号18182-40-6 (CH3)2NCH2Si(CH3)3 | CAS号75-31-0 异丙胺

专利信息

专利号:US-5760237-A
优先权日:1995-08-25
标 题 :Synthesis of l-azatyrosine using pseudoephedrine as a chiral auxiliary
发明人：MYERS ANDREW G
权利人:CALIFORNIA INST OF TECHN
摘要:A practical synthesis of the potential chemotherapeutic agent L-azatyrosine is described. The key step involved the alkylation of (R,R)-(-)-pseudoephedrine glycinamide with 5-benzenesulfonyloxy-2-iodomethylpyridine and proceeded in 70-95% yield and 89-95% de. Simultaneous hydrolysis of the auxiliary and the benzenesulfonate protecting group afforded L-azatyrosine of ≧99% ee in 73% yield on multigram scale (recovery yield of (R,R)-(-)-pseudoephedrine: 90%).

专利号:US-7420052-B2
优先权日:2001-08-24
标 题:Intermediates for synthesis of vinblastine, process for preparation of the intermediates and process for synthesis of vinblastines
发明人：FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI; YOKOSHIMA SATOSHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:An intermediate for vinblastine synthesis represented by general formula A. n ngeneral formula A.n n(in the formula, R 1 , R 2 , R 3 and R 4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R 5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R 6 is an alkyl group of carbon number 4 or less, R 7 is a substituted or non-substituted aryl group, R 8 is a substituted or non-substituted aryl group or lower alkyl group and R 9 is an acyl group or trialkylsilyl group.) A method for synthesis of the compound of general formula A utilizing radical ring forming reaction of thioanilides and using the compound of general formula B as the starting material, synthesizing thioanilide of general formula C by the reaction with compound 1 and the formation of a 11-membered ring by intramolecular alkylation of 2-nitrobenzenesulfonamide by which the reactions can proceed under mild conditions and high yield can be accomplished.

专利号:US-7183417-B2
优先权日:2004-04-09
标题:Simple stereocontrolled synthesis of salinosporamide A
发明人：COREY ELIAS J
权利人:HARVARD COLLEGE
摘要:A simple and effective stereocontrolled synthesis of salinosporamide A(1) n nhas been developed which follows the pathway outlined in the FIGURE. The process, the first total synthesis of salinosporamide A, is capable of providing the compound in substantial quantities for further biological studies. In addition to the method of Scheme I, the present invention also includes several novel synthetic intermediate compounds, several intermediate steps of the preferred synthetic process; and the uses of these compounds in the preparation of synthetic derivatives of the compound Salinosporamide A. Salinosporamide A is of special interest as a synthetic target because of its protein in vitro cytotoxic activity against many tumor cell lines (IC 50 values of 10 nM or less).

专利号:US-2019047933-A1
优先权日:2016-03-15
标 题:Process for the synthesis of (2e, 4e, 6z, 8e)-8-(3,4-dihydronaphthalen-1(2h)-ylidene)-3,7-dimethylocta-2, 4, 6-trienoic acid
发明人：ABEL ULRICH; RÉPÃ?SI JÓZSEF; Szabó András; SZÃœCSNÉ CSERÉPI STEFÃ?NIA; Bor Ã?dám
权利人:ABEL ULRICH; REPASI JOZSEF; SZABO ANDRAS; SZUECSNE CSEREPI STEFANIA; BOR ADAM; BRICKELL BIOTECH INC
摘要:This invention relates to a novel method for the synthesis of (2E,4E,6Z,8E)-8-(3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid. In particular, the invention relates to several improvements in several individual steps of the multi-step synthesis scheme

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-11891351-B2
优先权日:2020-03-20
标 题 :Synthesis of capsaicin derivatives
发明人：LAGER ERIK
权利人:AXICHEM AS
摘要:The present invention relates to the synthesis of capsaicin derivatives, specifically to the synthesis of 6-heptyne derivatives of capsaicin.