CAS: 40371-51-5; (S)-4-Amino-2-Hydroxybutanoic Acid

上下游产品

L-2,4-diaminobutyrate (S)-2-hydroxysuccinamic acid γ-phthalimidoimino-α-hydroxybutyric acid S-4-benzyloxycarbonylamino-2-hydroxybutyric acid (S)-3-hydroxypyrrolidin-2-one (S)-hydroxy-3 phenylacetyl-1 pyrrolidinone-2 S-4-benzyloxycarbonylamino-2-hydroxybutyric acid (S)-2-Hydroxy-4-(5-methyl-2-nitro-phenylamino)-butyric acid

专利信息

专利号:US-5763587-A
优先权日:1987-11-27
标题:Process for the synthesis of amikacin
发明人：MANGIA ALBERTO
权利人:GIST BROCADES ITALY SPA
摘要:In the synthesis of amikacin, having the formula: (I) by acylation of a diprotected derivative of kanamycin A with a reactive derivative of L-(-)-4-amino-2-hydroxybutyric acid, the selection of the reaction solvent and of the pH conditions permit the industrial economically and the synthesis yield to be improved.

专利号:US-4902790-A
优先权日:1985-10-10
标 题 :Novel process for the synthesis of amikacin
发明人：MANGIA ALBERTO; GIOBBIO VICENZO; ORNATO GIORGIO
权利人:PIERREL SPA
摘要:A novel process for the synthesis of amikacin starting from kanamycin A protected at the positions 3 and 6' is described comprising the reaction of kanamycin A with a salt of a bivalent metal cation selected from zinc, nickel, iron, cobalt, manganese, copper and cadmium in the presence of water as the solvent or co-solvent followed by the in situ reaction of the resulting complex with a reactive derivative of L-amino-2-hydroxy-butyric acid, removal of the metal cation of the protecting groups and purification of the thus obtained raw product. The acylation under these conditions is extremely selective.

专利号:ZA-888855-B
优先权日:1987-11-27
标题:A process for the synthesis of amikacin

专利号:EP-0218292-B1
优先权日:1985-10-10
标题:Novel process for the synthesis of amikacin

专利号:EP-0317970-A3
优先权日:1987-11-27
标题 :A process for the synthesis of amikacin

专利号:DD-283564-A5
优先权日:1987-11-27
标题 :PROCESS FOR THE SYNTHESIS OF AMIKACIN