CAS: 38398-32-2; Ganaxolone

上下游产品

别孕烯醇酮 Isopregnanolone 516-55-2
1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3-(Iodomethyl)-10,13-Dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-Tetradecahydrocyclopenta[a]Phenanthren-17-Yl]Ethanone 162882-87-3
(3R)-Spiro[oxirane-2',5α-Pregnan]-20-One 148256-45-5
氢化黄体酮 Dihydroprogesterone 566-65-4
孕烯醇酮 Pregnenolone 145-13-1

📜20,20-Ethylenedioxy-3β-Methyl-5α-Pregnan-3α-Ol置于potassium Dichromate,硫酸体系中,用 水,丙酮 作为反应溶剂,化学反应 2.0H,反应生成 加奈索酮
参考文献:Use Of Neurosteroids To Treat Neuropathic Pain
标题:Use Of Neurosteroids To Treat Neuropathic Pain
摘要:Ganaxolone(3α-羟基-3β-甲基-5β-孕酮-20-酮)和3α-羟基-3β-甲基-5β-孕酮-20-酮及其生理可分解的酯类对治疗神经病性疼痛有用.包含药用可接受的赋形剂和适当化合物的组合物以及制备该组合物的方法被披露.还披露了制造物品,其中该组合物与治疗神经病性疼痛的标签说明结合.

专利信息

专利号:US-8362286-B2
优先权日:2009-08-13
标题:Method for making 3α-hydroxy, 3β- substituted-5α-pregnan-20-ones
发明人：SHAW KENNETH; HUTCHISON ALAN
权利人:MARINUS PHARMACEUTICALS INC; SHAW KENNETH; HUTCHISON ALAN
摘要:Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α-pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione; with an organometallic methylating agent in an inert solvent to provide a compound of the formula