CAS: 3375-50-6; Coenzyme M

上下游产品

thirane water ethylene sulphide 2,2'-dithio-bis-ethane sulfonate 2-(acetylthio)ethane-1-sulfonic acid

📜美司那 反应生成 酪朊酸钠
参考文献:Pharmaceutical Compositions Having Therapeutical Activity Based On
标题:Pharmaceutical Compositions Having Therapeutical Activity Based On
摘要:L-精氨酸盐对巯基乙烷磺酸在膀胱癌治疗和囊性肾结石治疗和预防中具有活性.碱性氨基酸和它们的烷基酯盐的盐类衍生物也没有副作用.后者的衍生物是通过在水或水醇介质中反应刚刚从有机或无机盐制备的等摩尔量的巯基乙烷磺酸和所需氨基酸制备的.

专利信息

专利号:US-4105651-A
优先权日:1976-03-15
标 题:Purification of enkephalin, an endogenous composition in the human body and synthesis of same
发明人：HUGHES JOHN
权利人:US HEALTH EDUCATION & WELFARE
摘要:The purification of an endogenous composition isolated from mammalian brain tissue and termed enkephalin ('in the head'). Enkephalin is recovered from brain tissue by acetone solution and purified by means of column and thin layer chromatography. The composition which is a mixture of two pentapeptides, namely, (a) H-Tyr-Gly-Gly-Phe-Met-OH and (b) H-Tyr-Gly-Gly-Phe-Leu-OH wherein the ratio of a:b is from 3:1 to 4:1 has been found to be a non-addictive narcotic and an opiate agonist. n The synthesis of the pentapeptide composition from the known structure above is accomplished by conventional solution techniques of protection of the amino groups, such as t-butyloxycarbonyl, benzyloxycarbonyl, and t-amyloxycarbonyl, or the solid phase peptide synthesis of R. Bruce Merrifield using a polymeric support and the same or similar amine protecting groups.

专利号:US-8404804-B2
优先权日:2007-08-28
标 题 :Methods and intermediates for chemical synthesis of polypeptides and proteins
发明人：DONG ZHENG XIN; EYNON JOHN S
权利人:DONG ZHENG XIN; EYNON JOHN S; IPSEN PHARMA SAS
摘要:The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal N-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-(methylamino)-thioester intermediate that spontaneously rearranges to form an amide bond. Furthermore, the invention relates to methods of converting N-methyl-thiazolidine to N-methyl-cysteine (SEQ ID NO: 1) of polypeptides and proteins. The invention also relates to methods of synthesizing peptide-thioester from peptide-acid fluoride.

专利号:US-2010204449-A1
优先权日:2007-09-04
标 题 :Methods and intermediates for chemical synthesis of polypeptides and proteins
发明人：DONG ZHENG XIN; KIM SUN H
权利人:DONG ZHENG XIN; KIM SUN H
摘要:The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal β-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-amino-thioester intermediate that spontaneously rearranges to form an amide bond. The invention also relates to methods of synthesizing β-methyl-cysteine (SEQ ID NO: 1) and its protected forms. Furthermore, the invention relates to converting a β-methyl-thiazolidine residue to a β-methyl-cysteine (SEQ ID NO: 1) residue of polypeptides and proteins.

专利号:US-2010152468-A1
优先权日:2008-10-16
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; JADAV ARPAN M; DADHANIYA PRATISH; NALAWADE JITENDRA
权利人:TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-2021220331-A1
优先权日:2016-05-03
标题:Inhibitors of ires-mediated protein synthesis
发明人：GERA JOSEPH F; LICHTENSTEIN ALAN; JUNG MICHAEL E; LEE JIHYE; HOLMES BRENT; BENAVIDES-SERRATO ANGELICA
权利人:UNIV CALIFORNIA; THE UNITED STATE GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
摘要:This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.

专利号:US-2003232952-A1
优先权日:2001-02-02
标题:Design and synthesis of instant - degradable plastics
发明人：ROSEN OREN
摘要:A novel class of instant degradable synthetic polymeric plastics having the characteristics and properties of conventional forms of plastics is developed by providing a new application advantage of incorporating latent, labile, dormant chemical bond nuclei such as disulfide and sulfenyl derivatives of the plastic compounds with latent nucleophilic properties. The special advantage of the instant degradable polymers over the existing biodegradable and other degradable polymer counterparts, is their engineering and design, which makes the kinetics of their degradation instant, and the chemical and physical properties of their by-products allows soluble dissolution into non-toxic aqueous solvent media, thus enabling a practical treatment of waste and avoiding bio-hazardous pollution of the environment. These novel plastic products are made from a variety of compositions of polymers and their compatible nontoxic modifiers. The resulting novel instant degradable plastic products retain latent dormant solubility properties that are triggered upon mild chemical reaction, thus enabling cost effective and facile recycling of plastic refuge.