CAS: 27314-97-2; 3-Aminobenzo[e][1,2,4]Triazine 1,4-Dioxide

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CAS号5424-06-6 3-氨基苯并[e] [1,2,... | CAS号20028-80-2 1,2,4-苯并噻嗪-3-胺 | CAS号88-74-4 2-硝基苯胺 | CAS号528-29-0 1,2-二硝基苯 | CAS号67692-91-5 1,2,4-Benzotria... | CAS号27446-08-8 3-hydroxy-1,2,4... | CAS号5424-06-6 3-氨基苯并[e] [1,2,... | CAS号34371-14-7 (4S,5R)-4-羟基-5-... | CAS号20028-80-2 1,2,4-苯并噻嗪-3-胺

📜1,2,4-苯并噻嗪-3-胺置于过氧乙酸,间氯过氧苯甲酸体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 3.0H,反应生成替拉扎明
参考文献:替拉扎明和相关 1,2,4-苯并三嗪 N-氧化物的完整 1H,13C 和 15N NMR 归属
标题:替拉扎明和相关 1,2,4-苯并三嗪 N-氧化物的完整 1H,13C 和 15N NMR 归属
摘要:已对 3-氨基-1,2,4-苯并三嗪和一系列 N-氧化物进行了 1H,13C 和 15N NMR 测量(1D 和 2D 包括 1H15N Gs-Hmbc)并建立了完整的归属.除了 3-氨基-1,2,4-苯并三嗪 1-氧化物外,任何位置的 N-氧化都会导致相应的 N-1 和 N-2 共振的大的上场位移和 N-4 的下场位移,其中观测到 N-4 的小高场位移.15N 和 13C 化学位移的密度泛函 Giao 计算 [b3Lyp/6-31G(D)//b3Lyp/6-311 + G(2D,P)] 与确认分配的实验值非常吻合.13C 和 15N NMR 的组合提供了一种明确的方法来分配 1,2,4-苯并三嗪的 N-氧化物的 1H 和 13C 共振.版权所有 © 2006 John Wiley & Sons,Ltd.
Doi:10.1002/mrc.1886

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-8734846-B2
优先权日:2008-06-16
标 题 :Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
发明人：ALI MIR M; HRKACH JEFF; ZALE STEPHEN E; ALVAREZ DE CIENFUEGOS LUIS
权利人:BIND BIOSCIENCES INC
摘要:This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization fromâ€? approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling toâ€? that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonalâ€? chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.