CAS: 2675-79-8; 1-Bromo-3,4,5-Trimethoxybenzene

上下游产品

CAS号24313-88-0 3,4,5-三甲氧基苯胺 | CAS号619-42-1 对溴苯甲酸甲酯 | CAS号213596-33-9 4-甲氧基苯硼酸新戊二醇酯 | CAS号77-78-1 硫酸二甲酯 | CAS号4521-61-3 3,4,5-三甲氧基苯甲酰氯 | CAS号91-10-1 2,6-二甲氧基酚/紫丁香醇 | CAS号2539-27-7 Phenol,3,4,5-tr... | CAS号118-41-2 3,4,5-三甲氧基苯甲酸 | CAS号487-11-6 5-烯丙基-1,2,3-三甲氧基苯 | CAS号22699-97-4 Methanone,(3,4-... | CAS号220230-97-7 1,2,3-trimethox... | CAS号100-68-5 茴香硫醚 | CAS号634-36-6 1,2,3-三甲氧基苯 | CAS号6443-69-2 3,4,5-三甲氧基甲苯 | CAS号214360-67-5 3,4,5-三甲氧基苯硼酸频呢醇酯 | CAS号56772-00-0 3,3',4,4',5,5'-... | CAS号100-66-3 苯甲醚

1,2,3-三甲氧基苯置于potassium Bromide体系中,用 乙腈 用作溶剂,化学反应 8.0H,以90%的收率获得1-溴-3,4,5-三甲氧基苯
参考文献:使用铜基纳米催化剂对芳香族化合物进行高度区域选择性好氧溴化的新方法
标题:使用铜基纳米催化剂对芳香族化合物进行高度区域选择性好氧溴化的新方法
摘要:描述了一种在回流条件下在铜基纳米颗粒(cuo / Zno纳米催化剂)存在下对芳香族化合物进行高度区域选择性好氧溴化的新方法.讨论了机械参数并提出了合理的机制.在对芳香族化合物进行好氧溴化后,还研究了cuo / Zno纳米催化剂的可回收性.
Doi:10.2174/1570178616666190429145952

专利信息

专利号:US-8530689-B2
优先权日:2008-05-05
标 题 :Processes for the preparation of biphenyl compounds
发明人：PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J
权利人:PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J; UNIV PENNSYLVANIA
摘要:The invention concerns processes for the synthesis of a compound of the formula: wherein: R 1 and R 2 are each, independently, C 1 -C 12 alkyl, CO 2 R 3 , OR 4 , R 5 (OR 6 ), or C 6 -C 18 aryl; R 3 -R 6 are each, independently, C 1 -C 12 alkyl or C 6 -C 12 aryl; and n and m are each, independently, O or an integer from 1-5; said process comprising:—contacting a compound of the formula H0-R 7 -0H with BH 3 and a compound of the formula in the presence of a nickel-containing catalyst to produce a first product, where R 7 is a C 2 -C 12 hydrocarbon group and X is a halogen, OMs or OTs;—contacting the first product in situ with a compound of the formula: in the presence of a nickel-containing catalyst to produce a compound of formula I, where Z is a halogen.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-6943194-B1
优先权日:1998-01-09
标题:Synthesis of phenstatin and prodrugs thereof
发明人：PETTIT GEORGE R; TOKI BRIAN
权利人:UNIV ARIZONA STATE
摘要:A newly discovered antineoplastic compound denominated “phenstatinâ€? is herein described as are synthetic methods for producing phenstatin and the active prodrug thereof. Phenstatin was converted to the sodium phosphate prodrug (3d) by a dibenzylphosphite phosphorylation and subsequent hydrogenolysis sequence 3b→3c→3d. Phenstatin (3b) was found to be a potent inhibitor of tubulin polymerization and the binding of colchicine to tubulin comparable to combretastatin A-4 (1b).

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:WO-2024185814-A1
优先权日:2023-03-06
标题:Method for producing aryl compound containing tritylsulfanyl group
发明人：OKAZOE TAKASHI; NOZAKI KYOKO; GATZENMEIER Tim; LIU YUE
权利人:AGC INC; UNIV TOKYO
摘要:The present invention provides: a substrate for achieving the highly efficient synthesis of an aryl compound containing a tritylsulfanyl group; a method for producing a compound containing an SF 5 group using the substrate; and others. The present invention is a method for producing an aryl compound containing a tritylsulfanyl group, the method comprising thiotritylating a halogenated aryl compound represented by general formula (1) [wherein A 1 represents an aryl group that may have a substituent or a heteroaryl group that may have a substituent; and X represents a halogen atom] using [(triphenylmethyl)sulfanyl]potassium or [(triphenylmethyl)sulfanyl]sodium to produce an aryl compound containing a tritylsulfanyl group, the aryl compound being represented by general formula (2) [wherein A 1 is the same as A 1 in general formula (1); and Ph represents a phenyl group].

专利号:WO-9934788-A1
优先权日:1998-01-09
标 题:Synthesis of phenstatin and prodrugs thereof