CAS: 2243-54-1; 2-Naphthylisocyanate

上下游产品

CAS号93-09-4 2-萘甲酸 | CAS号10335-79-2 N,N-naphthaloyl... | CAS号1208-11-3 naphthalene-2-c... | CAS号141903-34-6 1-(2-萘甲酰基)咪唑 | CAS号116-16-5 六氯丙酮 | CAS号91-59-8 2-萘胺 | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号91-58-7 β-氯萘 | CAS号917-61-3 氰酸钠 | CAS号32315-10-9 三光气 | CAS号91-59-8 2-萘胺 | CAS号109091-53-4 2-(diethylamino... | CAS号5446-53-7 Hydrazinecarbox...

2-萘甲酸置于羟胺,N,N-二异丙基乙胺,对硝基苯磺酰氯体系中,用 四氢呋喃,水,乙腈 用作溶剂,化学反应 17.0H,反应生成2-萘基异氰酸酯
参考文献:N-甲基咪唑催化异羟肟酸通过洛森重排合成氨基甲酸酯
标题:N-甲基咪唑催化异羟肟酸通过洛森重排合成氨基甲酸酯
摘要:报道了一种有效的,一锅法,N-甲基咪唑 (Nmi) 通过 Lossen 重排加速合成芳香族和脂肪族氨基甲酸酯的方法.Nmi 是将异氰酸酯中间体转化为氨基甲酸酯的催化剂.此外,芳基磺酰氯与 Nmi 组合的效用最大限度地减少了在序列过程中经常观测到的异羟肟酸酯-异氰酸酯二聚体的形成.在目前的条件下,降低温度也是可能的,从而实现温和的协议.
Doi:10.1021/ol303424B

专利信息

专利号:US-10017481-B2
优先权日:2012-03-17
标 题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; PIETTRE ARNAUD; GOSALBES JEAN-FRANÇOIS; THOMMEN MARC
权利人:POLYPHOR AG
摘要:The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.

专利号:CN-120309562-A
优先权日:2025-04-03
标题:Photocatalytic synthesis method of 2-amino naphthoselenazole compound