CAS: 204255-02-7; (1R,5R,6R)-Ethyl 5-(Pentan-3-Yloxy)-7-Azabicyclo[4.1.0]Hept-3-Ene-3-Carboxylate

上下游产品

CAS号204254-96-6 5-(戊烷-3-基氧基)-7-... | CAS号204254-84-2 1,3-Benzodioxol... | CAS号77-95-2 D-(-)-奎宁酸 | CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号196618-13-0 奥司他韦 | CAS号204255-11-8 磷酸奥司他韦 | CAS号204255-06-1 5-叠氮奥塞米韦

📜奥司他韦杂质58置于sodium Azide,三氟甲磺酸三甲基硅酯,Dimethyl Sulfide Borane,Ammonium Chloride,Potassium Hydrogencarbonate,三甲基膦体系中,化学反应 21.2H,反应生成(1R,5R,6R)-5-(1-乙丙基)-7-氮杂双环[4.1.0]庚-3-烯-3-羧酸乙酯
参考文献:Practical Total Synthesis Of The Anti-Influenza Drug Gs-4104
标题:Practical Total Synthesis Of The Anti-Influenza Drug Gs-4104
摘要:
Doi:10.1021/jo980330Q

专利信息

专利号:US-6518438-B2
优先权日:1996-08-23
标题:Preparation of cyclohexene carboxylate derivatives
发明人：KENT KENNETH M; KIM CHOUNG U; MCGEE LAWRENCE R; MUNGER JOHN D; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; KELLY DAPHNE E; WILLIAMS MATTHEW A; ZHANG LIJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:US-9150498-B2
优先权日:2011-10-25
标题:Process for the preparation of oseltamivir and methyl 3-epi-shikimate
发明人：RAWAT VARUN; DEY SOUMEN; ARUMUGAM SUDALAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses high yielding enantioselective process for synthesis of Oseltamivir from readily available starting material, cis-1,4-butene diol. The process features incorporation of chirality using sharpless asymmetric epoxidation (AE) and diastereoselective Barbier allylation and construction of cyclohexene carboxylic acid ester core through a ring closing metathesis (RCM) reaction. Further also disclosed herein is synthesis of (−)-methyl 3-epi-shikimate.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.