CAS: 17916-88-0; N-Acetyl-D-Valine

相似化合物

96-81-1 3067-19-4 349-00-8

上下游产品

diethyl 2-N-acetylamino-2-isopropylmalonate 2-acetylamino-3-methyl-crotonic acid acetic anhydride D,L-valine 2-methyl-4-iso-propyl-4H-oxazolin-5-one 2-Acetamino-isovaleriansaeure- N-acetyl-DL-valine methyl ester 3-Acetyl-4-isopropyl-5-oxazolidinone

2-Methyl-4-Iso-Propyl-4H-Oxazolin-5-One置于氢溴酸体系中,用 四氢呋喃,硝基甲烷,水 用作溶剂,化学反应 7.0H,反应生成N-乙酰-D-缬氨酸
参考文献:对映体纯的环状和开放链(R)-和(S)-α,α-二取代α-氨基酸的新通用方法
标题:对映体纯的环状和开放链(R)-和(S)-α,α-二取代α-氨基酸的新通用方法
摘要:制备了各种各样的环状和开链α,α-二取代的α-氨基酸1A-P.通过与衍生自(S)-苯丙氨酸的手性胺15-18偶联,拆分外消旋n-酰化的α,α-二取代氨基酸,形成非对映异构体19/20或21/22,可以通过结晶和/或快速色谱分离在硅胶上(方案3).通过1,3-恶唑-5(4 H)-酮10A-P的选择性裂解以高收率得到相应的光学纯α,α-二取代氨基酸衍生物11或12(方案3).α,α-二取代氨基酸的绝对构型由非对映异构体20,21G',22D的x射线结构确定.
Doi:10.1002/hlca.19920750522

专利信息

专利号:US-9556221-B2
优先权日:2014-06-20
标题:N-acetyl amino acid ESTER derivatives of betulin and preparation method thereof
发明人：WANG YANG; ZHANG SHENG; DING WEIMING; YU TAO; YAN XIUFENG
权利人:UNIV NORTHEAST FORESTRY
摘要:The present invention disclosed N-acetyl amino acid ester derivatives of betulin and the preparation method thereof, the method comprising the steps that in the presence of an alkaline substance, a catalyst and a racemization-inhibitor, the carboxyl group of N-acetyl amino acid is activated by a coupling agent; and then the activated N-acetyl amino acid is reacted with betulin via esterification reaction to obtain the N-acetyl amino acid ester derivative of betulin. The present invention provided a simple synthesis method to synthesize the N-acetyl amino acid ester derivatives of betulin by using betulin as a precursor compound and modifying the molecular structure of betulin. Such structural modification of betulin significantly enhances the anti-tumor activity of the betulin derivatives and therefore has important values.

专利号:EP-0207580-B1
优先权日:1985-04-05
标题 :Process for the synthesis of n-acetyl amino acids from olefins, acetamide and syngas

专利号:EP-0207580-A1
优先权日:1985-04-05
标 题 :Process for the synthesis of N-acetyl amino acids from olefins, acetamide and syngas

专利号:US-2023089723-A1
优先权日:2020-03-06
标 题:Amino acid compositions and methods for muscle and myotube modulation
发明人：COMB WILLIAM; COKOL MURAT; KULKARNI TRIPTI
权利人:AXCELLA HEALTH INC
摘要:This disclosure provides compositions comprising amino acid entities. The disclosure also provides methods for increasing myogenesis, increasing muscle protein synthesis, increasing muscle mass, improving muscle quality or enhancing muscle function comprising administering an effective amount of the compositions to a subject in need thereof.