CAS: 1694-92-4; 2-Nitrobenzenesulfonyl Chloride

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CAS号88-74-4 2-硝基苯胺 | CAS号1155-00-6 2,2'-二硝基二苯二硫醚 | CAS号119-66-4 2-nitrobenzened... | CAS号7669-54-7 2-硝基苯硫氯 | CAS号7732-18-5 水 | CAS号7782-50-5 氯气 | CAS号7647-01-0 盐酸 | CAS号7697-37-2 硝酸 | CAS号7664-93-9 硫酸 | CAS号98-09-9 苯磺酰氯 | CAS号111711-70-7 5-ethoxy-1-(2-n... | CAS号54734-84-8 2-氨基-5-溴苯磺酰胺 | CAS号3306-62-5 2-氨基苯磺酰胺 | CAS号93-55-0 苯丙酮 | CAS号142529-01-9 1H-Pyrrole-2-ca... | CAS号436095-50-0 2-氨基-N-丙基苯磺酰胺 | CAS号495-40-9 苯丁酮 | CAS号20896-44-0 2,5-Diaminobenz... | CAS号16106-44-8 甲苯磺酸钾

双(2-硝基苯基)二硫化物置于氯,溶剂黄146体系中,化学反应生成邻硝基苯磺酰氯
参考文献:含哌嗪和芳基磺酰基部分的新型羧酰胺化合物的合成,生物学活性和sar研究
标题:含哌嗪和芳基磺酰基部分的新型羧酰胺化合物的合成,生物学活性和sar研究
摘要:合成了一系列包含哌嗪和芳基磺酰基部分的新型羧酰胺化合物19A-19J,20A-20J和22A-22D.生物测定结果表明,某些化合物对双子叶植物显示出非常好的除草活性,其中许多具有优异的抗真菌活性.其中24种新的化合物,表现出一些优势在商业杀真菌剂百菌清,烯酰吗啉,甲基硫菌灵,异菌脲,和菌素浓度为500 Mg / L.一些化合物在100μg/ Ml浓度下也表现出较高的kari抑制活性,可以用作新的kari铅抑制剂进行进一步研究.此外,使用不同的计算方法对这些新化合物的sar进行了全面研究,其中获得的3D-Qsar模型为进一步发现新的杀菌剂进行结构优化提供了有用的信息.这项研究的结果将有助于探索不同化学领域中含哌嗪化合物的全面生物活性.
Doi:10.1016/j.Ejmech.2016.04.005

专利信息

专利号:US-9988364-B1
优先权日:2017-03-21
标题 :Process for synthesis of Eliglustat and intermediate compounds thereof
发明人：LIU YU; YU GUANNENG; ZHENG ZHIGUO
权利人:ZHEJIANG AUSUN PHARMACEUTICAL CO LTD
摘要:The present invention relates to a process for synthesis of Eliglustat and intermediate compounds thereof. In particular, the present invention relates to a process for synthesis of Eliglustat and pharmaceutically acceptable salts thereof, and relates to the intermediate compounds in the process and a process for preparation of the intermediate compounds.

专利号:US-9475757-B2
优先权日:2013-05-03
标 题 :Synthesis of anti-Parkinson agent
发明人：MUTHUKRISHNAN MURUGAN; MUJAHID MOHAMMAD
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to an improved process for synthesis of anti-Parkinson compound of formula (I) from commercially available (R)-benzyl glycidyl ether, wherein the compound obtained has enantiopurity greater than >98%. Formula (I) wherein R 1 and R 2 are each independently selected from hydrogen or halogen.

专利号:US-2025236633-A1
优先权日:2022-03-28
标 题:Synthesis of isomerically pure polyol-based phosphoramidites
发明人：BANASIK BRENT; DIAZ CORRAL JULIAN ANDRES; JACOBS AARON; JUD LUKAS; KUCHELMEISTER HANNES; NBAVI MELUD; PFAFFENEDER TONI; SIMONYIOVA SONA; TABONE JOHN C; THUER WILMA
权利人:ROCHE SEQUENCING SOLUTIONS INC
摘要:The present disclosure relates to a process for the regiochemically and enantiomerically controlled synthesis of phosphoramidite-containing monomers, and to intermediate products of this process. In some embodiments, the phosphoramidite-containing monomers or their precursors are regioisomerically and/or enantiomerically pure and may be polymerized into polymers or copolymers.

专利号:WO-2024259491-A1
优先权日:2023-06-23
标 题:New synthesis method
发明人：FORD DANIEL; POZNAKS VIKTORS; FOTINS JURIS; ÄŒERÅ…AKS DMITRIJS
权利人:THE HEART RES INSTITUTE LTD
摘要:The present disclosure generally relates to a process for the synthesis of AZD6482. In particular, the present disclosure also relates to a process for the synthesis of enantiomerically pure AZD6482. The present disclosure also relates to a process for the synthesis of enantiomerically pure intermediates. The present disclosure also relates to compounds prepared by the processes and the use of such compounds to prepare compositions and to treat disorders.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-7423154-B2
优先权日:2001-03-07
标 题 :Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates
发明人：BROWN WILLIAM; PLOBECK NIKLAS
权利人:ASTRAZENECA AB
摘要:An asymmetric synthesis of diarylmethylpiperazines is described. The synthetic route enables preparation of a variety of enatiomerically pure amines with different N-alkyl groups. The invention includes an asymmetric addition of organometallic compounds to chiral sulfinimine to give adducts in predominantly one diastereomer can subsequently be transferred into pure enantiomers of by cleavage of the chiral auxilliary which is followed by synthesis of the piperazine ring by alkylation procedures.