CAS: 1313881-70-7; 3-(3-(4-(1-Aminocyclobutyl)Phenyl)-5-Phenyl-3H-Imidazo[4,5-B]Pyridin-2-yl)Pyridin-2-Amine

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Tert-Butyl (1-(4-(2-(2-Aminopyridin-3-yl)-5-Phenyl-3H-Imidazo[4,5-B]Pyridin-3-yl)Phenyl)Cyclobutyl)Carbamate 1313881-69-4

合成工艺路线路线简述

    📜2-氯-3-硝基-6-苯基吡啶置于甲烷磺酸,Palladium 10% On Activated Carbon,氢气,Sodium Carbonate,溶剂黄146体系中,用 四氢呋喃,甲醇,N,N-二甲基乙酰胺 用作溶剂,20.0~100.0 °C,275.8 Kpa 条件下,反应 87.5H,反应生成3-[3-[4-(1-氨基环丁基)苯基]-5-苯基-3H-咪唑并[4,5-B]吡啶-2-基]-2-吡啶胺
    参考文献:Process Of Preparing 3-(3-(4-(1-Aminocyclobutyl)Phenyl)-5-Phenyl-3H-Imidazo[4,5-B]Pyridin-2-yl)Pyridin-2-Amine
    标题:Process Of Preparing 3-(3-(4-(1-Aminocyclobutyl)Phenyl)-5-Phenyl-3H-Imidazo[4,5-B]Pyridin-2-yl)Pyridin-2-Amine
    摘要:本发明涉及一种合成3-(3-(4-(1-氨基环丁基)苯基)-5-苯基-3H-咪唑并[4,5-B]吡啶-2-基)吡啶-2-胺的方法.

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    专利信息


    专利号:US-11858953-B2
    优先权日:2018-04-04
    标 题:Compositions and methods for synthesis of phosphorylated molecules
    发明人:CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
    权利人:UNIV CALIFORNIA
    摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

    专利号:US-7741475-B2
    优先权日:2006-02-13
    标题:Synthesis of monovalent and polyvalent arabinans and mannose-capped arabinans of the protective cell-wall coat of mycobacterium tuberculosis
    发明人:FRASER-REID BERTRAM; LU JUN
    权利人:NATURAL PRODUCTS & GLYCOTECHNO
    摘要:The present application provides arabinans and mannose-capped arabinan compositions of formulas I-VIII, described herein, and methods of making the compositions.

    专利号:US-9834556-B2
    优先权日:2014-03-24
    标题 :Process of preparing 3-(3-(4-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-YL)pyridin-2-amine
    发明人:BATES CRAIG; CHEN JIAN-XIE; MAO JIANMIN; REED DAVID P
    权利人:ARQULE INC
    摘要:The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:

    专利号:US-10188136-B2
    优先权日:2016-02-16
    标题:Hydrophobin mimics: process for preparation thereof
    发明人:BRITTO Sandanaraj Selvaraj; REDDY Mullapudi Mohan; BHANDARI PAVANKUMAR JANARDHAN; RAO KASULADEVU JAGANNADHA
    权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES
    摘要:The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles/nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.

    专利号:US-2003069212-A1
    优先权日:2001-07-30
    标 题 :Synthesis of A-ring synthon of 19-nor-1alpha, 25-dihydroxyvitamin D3 from (D)-glucose

    专利号:US-2008015344-A1
    优先权日:2006-02-13
    标 题:Synthesis of monovalent and polyvalent arabinans and mannose-capped arabinans of the protective cell-wall coat of mycobacterium tuberculosis

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    主要参考文献


    1: Naik GAP, Paradkar O, Sharma V, Kumar S, Gupta P, Wadhwa P. A computational journey in anticancer drug discovery: Exploring AKT1 inhibition by novel oxadiazoles using molecular docking, ADMET, density functional theory and molecular dynamic simulation. Comput Biol Chem. 2025 Aug;117:108425. doi: 10.1016/j.compbiolchem.2025.108425. Epub 2025 Mar 16.
    284:116854. doi: 10.1016/j.ecoenv.2024.116854. Epub 2024 Aug 13.
    348:199447. doi: 10.1016/j.virusres.2024.199447. Epub 2024 Aug 9.

    合成参考文献


    参考文献:10.1371/journal.pone.0140479
    摘要:Yu Y, Savage RE, Eathiraj S, Meade J, Wick MJ, Hall T, Abbadessa G, Schwartz B. Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092. PLoS ONE. 2015 Oct 15;10(10):e0140479. doi: 10.1371/journal.pone.0140479.
    参考文献:10.1038/s41401-022-00862-1
    摘要:Liu X, Zhang G, Huang S, Shi W, Ye L, Ren Z, Zhang J, Liu S, Yu L, Li Y. PTEN loss confers sensitivity to rapalogs in clear cell renal cell carcinoma. Acta Pharmacologica Sinica. 2022 Feb 14;43(9):2397–409. doi: 10.1038/s41401-022-00862-1.
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