CAS: 121584-18-7; Valspodar

📜,二氯乙酸置于二氯乙酸体系中,用54的收率获得戊司泊达; 伐司扑达
参考文献:Cyclosporins And Their Use As Pharmaceuticals
标题:Cyclosporins And Their Use As Pharmaceuticals
摘要:环孢霉素中,1-位置上的残基(通常为-Mebmt-或-Dihydro-Mebmt-)是3'O-酰化或3'-氧化或-C.Sub.1-4烷氧基亚胺取代的,或者2-位置上的残基是β-O-酰基或β-氧代取代的,或者2-位置上的残基是-Ile-,或者11-位置上的残基是-Meals-,-Meile-或-Mealloile-以及各种天然存在的环孢霉素/二氢衍生物,在逆转化疗药物抵抗性方面有用,特别是对细胞毒性或抗肿瘤治疗的抵抗性.其中的一些环孢霉素和其生产的中间体是新颖的.在1-位置上的残基(例如-Mebmt-,-Dihydro-Mebmt-等)为8'-烷氧基或7'-去甲基-7'-羟基烷基取代的中间体是新颖的,并且作为免疫抑制剂,抗炎和抗寄生虫剂是有用的.

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-2006014987-A1
优先权日:2003-07-07
标 题:Synthesis of beta-elemene, intermediates thereto, analogues and uses thereof
发明人：HUANG LAN
权利人:HUANG LAN
摘要:The present invention provides convergent processes for preparing beta-elemene, and analogues thereof. Also provided are analogues related to beta-elemene and intermediates useful for preparing the same. The present invention further provides novel compositions based on analogues of beta-elemene and methods for the treatment of cancer, such as brain tumor, lung cancer, colorectal cancer, gastric intestional cancer, and stomach cancer.

专利号:US-2025241876-A1
优先权日:2023-07-19
标 题:Anti-tumor compounds and methods of use thereof and synthesis thereof
发明人：QUAY STEVEN CARL
权利人:ATOSSA THERAPEUTICS INC
摘要:Described herein are pharmaceutical compounds and compositions and methods of making thereof. Methods of synthesis for the compounds are described herein. The compounds or compositions described herein may exhibit aromatase inhibition activity or estrogen receptor activity. The compounds and compositions described herein may be useful in the treatment of a condition in a subject.

专利号:US-2023192682-A1
优先权日:2019-11-14
标题:Improved synthesis of kras g12c inhibitor compound

专利号:US-2023192681-A1
优先权日:2019-11-14
标 题 :Improved synthesis of kras g12c inhibitor compound