专利号:US-4469701-A 优先权日:1983-06-23 标题 :Pyrrolid-3-en-2-ones and pharmaceutical methods of use thereof 发明人:DEBAUN JACK R; PALLOS FERENC M; MATSUMOTO KENT E; ROSS JOHN H 权利人:STAUFFER CHEMICAL CO 摘要:Novel compounds having the structural formula ##STR1## wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, thioalkyl, thiohaloalkyl, alkoxy, cyano and nitro are provided. The compounds have various pharmacological effects, including cardiotropic, hypoglycemic, hypocholesterolemic and/or antiulcerative effects in mammals. Methods of achieving these various pharmacological effects in mammals by administering the compounds thereto are provided. Pharmaceutical compositions and formulations including the compounds are provided along with methods of synthesis of the novel compounds.
专利号:US-8507693-B2 优先权日:2010-03-03 标 题:Process for synthesis of fipronil 发明人:GHARDA KEKI HORMUSJI 权利人:GHARDA KEKI HORMUSJI 摘要:The present disclosure relates to a process for trifluoromethylsulfinyl pyrazole compound of formula I, n nfrom a compound of formula III, wherein, R, R 1 and R 2 represent a group containing halogen group respectively and R 3 represents a perhaloalkyl.
专利号:US-4209464-A 优先权日:1977-06-10 标题:Novel synthesis of 3-amino-2-methylbenzotrifluoride from N-(2-X-5-trifluoromethylphenyl)-S,S-dimethylsulfimide 发明人:STEINMAN MARTIN; WONG YEE S 权利人:SCHERING CORP 摘要:This invention relates to a novel process for preparing 3-amino-2-methylbenzotrifluoride, and to certain novel intermediates produced by the process. 3-Amino-2-methylbenzotrifluoride is a key intermediate useful in the preparation of valuable therapeutic agents such as, for example, 2-(2-methyl-3-trifluoromethyl)anilino nicotinic acid.
专利号:WO-2011107998-A1 优先权日:2010-03-03 标题 :Process for synthesis of fipronil
专利号:US-4656291-A 优先权日:1985-03-15 标 题 :Process for producing amidine sulfonic acids 发明人:MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C 权利人:MCNEILAB INC 摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.
专利号:US-4781866-A 优先权日:1985-03-15 标题 :Process for producing amidine sulfonic acid intermediates for guanidines 发明人:MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C 权利人:MCNEILAB INC 摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 56. 摘要:Camp, J. E., Science of Synthesis Knowledge Updates, (2012) 1, 333. 摘要:Hay, M. B.; Hicks, J. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 114. 摘要:Schafer, E.W. 1972. The acute oral toxicity of 369 pesticidal, pharmaceutical and other chemicals to wild birds. Toxicology and Applied Pharmacology. 21:315-330. 摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/Q_schafer832.pdf