CAS: 111-58-0; Oleoylethanolamide

相似化合物

142-78-9 142-58-5 23054-60-6

上下游产品

cis-°Ctadecenoic acid ethanolamine (Z)-9-°Ctadecenoyl chloride O-oleoylethanolamide trifluoroacetateNAEPA Phosphoric acid dibenzyl ester 2-((Z)-°Ctadec-9-enoylamino)-ethyl ester 2-(8-heptadecenyl)-2-oxazoline N-[(9Z)-1-oxo-9-°Ctadecenyl]glycine

油酸置于氯化亚砜,三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 1.25H,反应生成油酰乙醇胺
参考文献:Alkyl Sulfonyl Derivatized Pamam-G2Dendrimers As Nonviral Gene Delivery Vectors With Improved Transfection Efficiencies
标题:Alkyl Sulfonyl Derivatized Pamam-G2Dendrimers As Nonviral Gene Delivery Vectors With Improved Transfection Efficiencies
摘要:构建了基于两亲性树枝状大分子的基因递送载体,其外围带有烷基磺酰疏水尾,以低代数pamam-G2为核,通过其一级氨基组与乙烯基砜衍生物的氮-迈克尔型加成反应进行功能化,作为表面工程的有效工具.虽然未修饰的pamam-G2无法有效地转染真核细胞,但功能化的pamam-G2树枝状大分子能够在低n/p比下结合dna,保护dna免受dnase I的消化,并显示出高转染效率和低细胞毒性.带有c18烷基链的树枝状大分子在cho-K1细胞中的转染效率比lipofectamine™ 2000高出3.1倍.以功能化pamam-G2为基础的树枝状聚合物复合物也显示出在血清存在下保持其转染特性的能力,并能够转染不同的真核细胞系,如neuro-2A和raw 264.7.利用乙烯基砜化学,制备了这些载体的荧光pamam-G2衍生物,作为分子探针,通过非网格蛋白依赖的机制确定细胞摄取和内化.
Doi:10.1039/c0Ob00355G

专利信息

专利号:US-9522192-B2
优先权日:2012-12-13
标 题:Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides
发明人：CALIGNANO ANTONIO; D'AGOSTINO GIUSEPPE; LANERI SONIA; MELI ROSARIA; OSTACOLO CARMINE; RUSSO ROBERTO; SACCHI ANTONIA; TRONINO DIANA; DELLA VALLE FRANCESCO; DELLA VALLE MARIA FEDERICA; MARCOLONGO GABRIELE
权利人:EPITECH GROUP SRL
摘要:The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues—particularly in the skin and mucosae—and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.

专利号:US-12194020-B2
优先权日:2017-12-22
标 题:Reversing baldness through cannabinoid receptor activation
发明人：POSTREL RICHARD
权利人:POSTREL RICHARD
摘要:This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.

专利号:US-2023346952-A1
优先权日:2015-09-22
标题:Cannabinoid glycoside prodrugs and methods of synthesis
发明人：ZIPP BRANDON J; HARDMAN JANEE’ M; BROOKE ROBERT T; DEUTSCHER TYREL R
权利人:GRAPHIUM BIOSCIENCES INC
摘要:The present invention provides tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs and pharmaceutical compositions comprising these compounds, and their use for the site-specific delivery of tetrahydrocannabinol or cannabidiol. Also provided are processes for the preparation of purified tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs.

专利号:US-7888394-B2
优先权日:2006-08-21
标 题:Synthesis, polymorphs, and pharmaceutical formulation of FAAH inhibitors
发明人：PUTMAN DAVID; DASSE OLIVIER
权利人:ORGANON NV
摘要:Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. The alkylcarbamic acid aryl ester of Formula (I), KDS-4103, is a FAAH inhibitor. Described herein is a process for the preparation of the compound of Formula (I), characterization of polymorphs of the FAAH inhibitor, and their uses therof.

专利号:US-11407837-B2
优先权日:2017-09-11
标 题 :GPCR binding proteins and synthesis thereof
发明人：GLANVILLE JACOB
权利人:TWIST BIOSCIENCE CORP
摘要:Provided herein are methods and compositions relating to G protein-coupled receptor (GPCR) libraries having nucleic acids encoding for a scaffold comprising a GPCR binding domain. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

专利号:US-11207414-B2
优先权日:2015-09-22
标 题 :Cannabinoid glycoside prodrugs and methods of synthesis
发明人：ZIPP BRANDON J; HARDMAN JANEE M; BROOKE ROBERT T
权利人:GRAPHIUM BIOSCIENCES INC
摘要:The present invention relates to cannabinoid glycoside prodrugs suitable for site- and tissue-specific delivery of cannabinoid molecules. The present invention also relates to methods of forming the cannabinoid glycoside prodrugs through glycosyltransferase mediated glycosylation of cannabinoid molecules.