CAS: 956034-07-4; 2,4-Dichlorofuro[3,2-D]Pyrimidine

• 英文名称2,4-Dichlorofuro[3,2-D]Pyrimidine
• 中文名称2,4-二氯呋喃并[3,2-d]嘧啶
• IUPAC名称2,4-dichlorofuro[3,2-d]pyrimidine
• 其它别名2,4-二氯呋喃[3,2-D]并嘧啶; 24二氯呋喃并32D嘧啶; Furo[3,2-D]Pyrimidine, 2,4-Dichloro-; 2,4-Dichlorofuro[3,2-D]Pyrimidine
• CAS编号956034-07-4
• MFCD编号:MFCD11520866
• 分子式:C6H2Cl2N2O
• 分子量:189.0
• 产品CID: 2009366
• 产品分类有机原料→分子砌块→芳杂环类化合物→呋喃类化合物

• 相似结构搜索
• InChIKey: OTFDNOQBJWBJJM-UHFFFAOYSA-N
• InChI=1S/C6H2Cl2N2O/c7-5-4-3(1-2-11-4)9-6(8)10-5/h1-2H…
• 计算化学: 氢键受体数3.0氢键供体数0可旋转键数0

相似化合物

物理性质

• 沸点223.7±22.0 °C at 760 mmHg
• 闪点89.1±22.3 °C
• 密度1.6±0.1 g/cm3
• pKa:-1.02±0.40(预测)
• PSA:38.92
• LogP:2.5296
• 折射率1.646
• 蒸汽压0.1±0.4 mmHg at 25°C
• 外观形态浅黄色 粉末
• 储存条件在惰性气体(氮气或氩气)下 2-8°C
• 产品应用该化合物用于制备磷酰胺3基酶抑制剂的外皮酰胺衍生物.

MSDS等安全信息

• GHS符号GHS07
• 警示词Warning
• 危险描述H302-H315-H319-H335
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• 危险品标志Xn
• 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body

上下游产品

合成工艺路线路线简述

• 合成目标产物 2,4-Dichlorofuro[3,2-D]Pyrimidine 主要起始原料 Furo[3,2-D]Pyrimidine-2,4-Diol
• 956034-06-3 = 956034-07-4
  反应条件:1.1 Reagents: Phosphorus Oxychloride; Rt -> -40 °C1.2 Catalysts: Diisopropylethylamine; -40 °C; 48 H,-40 °C -> Reflux; Reflux -> Rt
  标题:Rational Design Of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity Over The Phosphoinositide 3-Kinase β Isoform
  作者:Heffron,Timothy P.; Wei,Bin Qing; Olivero,Alan; Staben,Steven T.; Tsui,Vickie; Et Al
  参考文献:Journal Of Medicinal Chemistry 日期:2011 卷标:54(22) 页码:7815-7833]
  
  956034-06-3 = 956034-07-4
  反应条件:1.1 Reagents: Diisopropylethylamine,Phosphorus Oxychloride; Rt -> -40 °C; -40 °C; 48 H,-40 °C -> Reflux; Reflux -> Rt1.2 Reagents: Water
  标题:Thienopyrimidine And Furopyrimidine Derivatives As Phosphoinositide 3-Kinase Inhibitor And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Cancer
  参考文献:World Intellectual Property Organization]
  
  956034-06-3 = 956034-07-4
  反应条件:1.1 Reagents: Diisopropylethylamine,Phosphorus Oxychloride; Rt -> -40 °C; -40 °C; 48 H,-40 °C -> Reflux; Reflux -> Rt
  标题:Preparation Of Thienopyrimidines And Furopyrimidines As Lipid Kinase Inhibitors For Treating Cancer And Other Diseases
  参考文献:World Intellectual Property Organization]
  
  956034-06-3 = 956034-07-4
  反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: N,N-Dimethylaniline; 2 H,130 °C; 130 °C -> Rt1.2 Reagents: Water; Cooled
  标题:Preparation Of Furanopyrimidines As Inhibitors Of Phosphatidylinositol 3-Kinase
  参考文献:World Intellectual Property Organization]
  
  956034-06-3 = 956034-07-4
  反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide; 5 H,Reflux
  标题:Preparation Of Fused Heterocyclic Compound Derivative As Parp-1/pi3K Dual-Target Inhibitor And Used For The Treatment Of Tumors
  参考文献:China]
  
  956034-06-3 = 956034-07-4
  反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide; Reflux
  标题:Identification Of 2,4-Diamino-6,7-Dimethoxyquinoline Derivatives As G9A Inhibitors
  作者:Srimongkolpithak,Nitipol; Sundriyal,Sandeep; Li,Fengling; Vedadi,Masoud; Fuchter,Matthew J.
  参考文献:Medchemcomm 日期:2014 卷标:5(12) 页码:1821-1828]
  
  956034-06-3 = 956034-07-4
  反应条件:1.1 Reagents: N,N-Dimethylaniline,Phosphorus Oxychloride; 3 H,130 °C; 130 °C -> Rt1.2 Reagents: Water; Cooled
  标题:Preparation Of Heterocyclic Compounds As Janus Kinase Inhibitors
  参考文献:World Intellectual Property Organization]
  
  956034-06-3 = 956034-07-4
  反应条件:1.1 Reagents: Diisopropylethylamine,Phosphorus Oxychloride; Rt -> -40 °C; -40 °C; 48 H,-40 °C -> Reflux; Reflux -> Rt1.2 Reagents: Water; Cooled
  标题:Preparation Of 4-Morpholinothienopyrimidine And 4-Morpholinofuropyrimidine Derivatives As Phosphoinositide 3-Kinase Inhibitors
  参考文献:World Intellectual Property Organization]
  
  956034-06-3 = 956034-07-4
  反应条件:1.1 Reagents: Diisopropylethylamine,Phosphorus Oxychloride; Rt -> -40 °C; -40 °C; -40 °C -> Reflux; 48 H,Reflux; Reflux -> Rt1.2 Reagents: Water; Cooled
  标题:Preparation Of 4-(Morpholino)Thienopyrimidines And 4-(Morpholino)Furopyrimidines As Phosphoinositide 3-Kinase Inhibitors And Their Pharmaceutical Compositions
  参考文献:World Intellectual Property Organization]
  
  956034-06-3 = 956034-07-4
  反应条件:1.1 Reagents: Diisopropylethylamine,Phosphorus Oxychloride; -40 °C; 10 Min,-40 °C; 24 H,Reflux; Reflux -> Rt1.2 Reagents: Water; Cooled
  标题:Five-And-Six-Membered Heterocyclic Compound,Its Preparation Method And Pharmaceutical Application
  参考文献:World Intellectual Property Organization]
  
  956034-06-3 = 956034-07-4
  反应条件:1.1 Reagents: Phosphorus Oxychloride Catalysts: Dimethylformamide; 5 H,110 °C; 110 °C -> Rt1.2 Reagents: Water; Cooled
  标题:Discovery Of Novel And Potent Parp/pi3K Dual Inhibitors For The Treatment Of Cancer
  作者:Wu,Zhengyang; Bai,Ying; Jin,Jiaming; Jiang,Teng; Shen,Hui; Et Al
  参考文献:European Journal Of Medicinal Chemistry 日期:2021 卷标:217]
  
  917-61-3 + 956034-04-1 = 956034-07-4
  反应条件:1.1 Reagents: Acetic Acid Solvents: Water; Rt; 5 H,Rt1.2 Reagents: Phosphorus Oxychloride Solvents: N,N-Dimethylaniline; Rt; 3 H,Reflux
  标题:Process For Preparation Of Pyrimidine Derivative And Its Application
  参考文献:China

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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• ➥ REACH监管