CAS: 910209-21-1; Cyclopropanesulfinic Acid Sodium Salt

该化合物是一种有机硫化合物,其特点是存在环丙烷环和硫酸组,典型的是一种钠盐,可增加其在水中的溶性;该化合物在有机合成中的潜在应用,特别是因其作为核素反应的能性能而作为各种化学反应中的试剂而闻名;环丙烷硫酸钠可能表现出在标准条件下具有稳定性等特性,但可能对热和湿度敏感;其再活性可归因于硫酸组的存在,可参与氧化和减少反应;此外,环丙烷的突变性会影响化合物的消毒和电子特性,使其在合成更为复杂的分子时有用;在处理之前,应先查阅安全数据,如处理任何化学物质,以确保采取适当预防措施.

英文名称Cyclopropanesulfinic Acid Sodium Salt
中文名称环丙烷亚磺酸钠
IUPAC名称Cyclopropanesulfinic acid sodium salt
其它别名环丙基亚磺酸钠; Sodium Cyclopropylsulfite
CAS编号910209-21-1
MFCD编号:MFCD08276208
EINECS号:837-232-4
分子式:C3H5NaO2S
分子量:128.13
产品CID: 1944624
产品分类有机原料→分子砌块→脂肪环类化合物→环丙烷类化合物

相似结构搜索
InChIKey: CQSFZPDGBPHCHV-UHFFFAOYSA-M
InChI=1S/C3H6O2S.Na/c4-6(5)3-1-2-3;/h3H,1-2H2,(H,4,5);/q;+1/p-1…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数1.0

相似化合物

761365-62-2 21297-68-7 2940933-44-6

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

欧盟法规

C&L通报

上下游产品

cyclopropanesulfonyl chloride9H10FNO2SC9H10FNO2S 4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-b]pyridine methyl 3-((1R)-3-(benzyloxy)cyclopentyl)-2-(4-(cyclopropylsulfonyl)-1H-indazol-1-yl)propanoate 6-(cyclopropylsulfonyl)-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole

合成工艺路线路线简述

合成目标产物 Cyclopropanesulfinic Acid, Sodium Salt 主要起始原料 Cyclopropanesulfonyl Chloride
139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 4 H,80 °C
标题:Rapid Synthesis Of β-Chiral Sulfones By Ni-Organophotocatalyzed Enantioselective Sulfonylalkenylation Of Alkenes
作者:Liu,Ming-Shang; Shu,Wei
参考文献:Jacs Au 日期:2023 卷标:3(5) 页码:1321-1327]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; Rt; 24 H,80 °C
标题:Rapid And Scalable Halosulfonylation Of Strain-Release Reagents
作者:Pickford,Helena D.; Ripenko,Vasyl; Mcnamee,Ryan E.; Holovchuk,Serhii; Thompson,Amber L.; Et Al
参考文献:Angewandte Chemie 日期:2023 卷标:62(3)]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Sulfite Solvents: Water; 10 Min,Rt1.2 Reagents: Sodium Carbonate; 10 Min,50 °C1.3 50 °C; 2 H,50 °C
标题:Expedient Synthesis Of Biologically Important Sulfonylmethyl Pyrimidines
作者:Blades,Kevin; Demeritt,Julie; Fillery,Shaun; Foote,Kevin M.; Greenwood,Ryan; Et Al
参考文献:Tetrahedron Letters 日期:2014 卷标:55(29) 页码:3851-3855]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 3 H,80 °C
标题:Visible-Light-Induced,Palladium-Mediated Desaturation/sulfonation Cascade To Access 4-Sulfonyltetrahydropyridine Scaffolds
作者:Lu,Wei-Dong; Zheng,Yu; Zhang,Zhi-Peng; Chen,Hong-Bin; Chen,Kai; Et Al
参考文献:Organic Letters 日期:2023 卷标:25(32) 页码:6077-6081]

6863-32-7 = 910209-21-1
反应条件:1.1 Reagents: Methyl Acrylate Catalysts: Sodium Acetate Solvents: Tetrahydrofuran,Water; 18 H,Rt1.2 Reagents: M-Chloroperbenzoic Acid Solvents: Dichloromethane; Rt1.3 Reagents: Sodium Hydroxide Solvents: Water; Rt1.4 Reagents: Sodium Hydroxide Solvents: Methanol,Dichloromethane; 0 °C
标题:Amine-Catalyzed Copper-Mediated C-H Sulfonylation Of Benzaldehydes Via A Transient Imine Directing Group
作者:Higham,Joe I.; Bull,James A.
参考文献:Angewandte Chemie 日期:2022 卷标:61(27)]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 4 H,80 °C
标题:Electrochemistry Enabled Nickel-Catalyzed Selective C-S Bond Coupling Reaction
作者:Wang,Yang; Zhang,Feng; Wang,Yi; Pan,Yi
参考文献:European Journal Of Organic Chemistry 日期:2022 卷标:2022(5)]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 3 H,80 °C
标题:Visible-Light-Mediated Three-Component Radical Iodosulfonylative Cyclization Of Enynes
作者:Cheng,Qi; Zhang,Fengrong; Chen,Xiaoyun; Han,Ying; Yan,Chaoguo; Et Al
参考文献:Organic Letters 日期:2022 卷标:24(13) 页码:2515-2519]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 24 H,80 °C
标题:Rapid And Scalable Halosulfonylation Of Strain-Release Reagents
作者:Pickford,Helena D.; Ripenko,Vasyl; Mcnamee,Ryan E.; Holovchuk,Serhii; Thompson,Amber L.; Et Al
参考文献:Chemrxiv 日期:2022 卷标:1 页码:1-10]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 3 H,80 °C
标题:Direct Sulfonylation Of Anilines Mediated By Visible Light
作者:Johnson,Tarn C.; Elbert,Bryony L.; Farley,Alistair J. M.; Gorman,Timothy W.; Genicot,Christophe; Et Al
参考文献:Chemical Science 日期:2018 卷标:9(3) 页码:629-633]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 4 H,80 °C
标题:Electrochemical Radical-Radical Cross-Coupling Approach Between Sodium Sulfinates And 2H-Indazoles To 3-Sulfonylated 2H-Indazoles
作者:Kim,Wansoo; Kim,Hun Young; Oh,Kyungsoo
参考文献:Organic Letters 日期:2020 卷标:22(16) 页码:6319-6323]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 4 H,80 °C
标题:Photo-Induced Imino Functionalizations Of Alkenes Via Intermolecular Charge Transfer
作者:Zhang,Xiang-Xin; Zheng,Hao; Mei,Yong-Kang; Liu,Yan; Liu,Ying-Ying; Et Al
参考文献:Chemical Science 日期:2023 卷标:14(40) 页码:11170-11179]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 3 H,80 °C
标题:Green And Efficient Synthesis Of Pure β-Sulfonyl Aliphatic Sulfonyl Fluorides Through Simple Filtration In Aqueous Media
作者:Feng,Kang; Wang,Jian-Bai; Zhang,Wei-Dong; Qin,Hua-Li
参考文献:Organic & Biomolecular Chemistry 日期:2023 卷标:21(24) 页码:4967-4971]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 4 H,80 °C
标题:Photo/ni Dual-Catalyzed Radical Defluorinative Sulfonylation To Synthesize Gem-Difluoro Allylsulfones
作者:Xu,Yiran; Wang,Shengchun; Liu,Zhao; Guo,Mian; Lei,Aiwen
参考文献:Chemical Communications (Cambridge 日期:2023 卷标:59(25) 页码:3707-3710]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 4 H,80 °C
标题:Metal-Free Sulfonylation Of Quinoxalinones To Access 2-Sulfonyl-Oxylated Quinoxalines Via Oxidative O-S Cross Coupling
作者:Shi,Shi-Hui; Yao,Yi-Fan; He,Jiao; Li,Hao-Yu; Han,Shao-Jie; Et Al
参考文献:Organic & Biomolecular Chemistry 日期:2023 卷标:21(9) 页码:1903-1909]

139631-62-2 = 910209-21-1
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Sulfite Solvents: Water; 12 H,80 °C
标题:Time And Atom Economical Regio- And Chemoselective Radical Cyclization Of Unactivated 1,6-Enynes Under Metal- And Oxidant-Free Conditions
作者:Mutra,Mohana Reddy; Li,Jing; Chen,Yu-Ting; Wang,Jeh-Jeng
参考文献:Chemistry - A European Journal 日期:2022 卷标:28(42)

环丙磺酰氯置于碳酸氢钠,Sodium Sulfite体系中,用水作为反应溶剂,化学反应 4.0H,以70%的收率获得产物环丙基亚磺酸钠
参考文献:亚磺酸钠与2H-吲唑之间的电化学自由基-自由基交叉偶联方法成为3-磺酰化2H-吲唑.
标题:亚磺酸钠与2H-吲唑之间的电化学自由基-自由基交叉偶联方法成为3-磺酰化2H-吲唑.
摘要:在电化学条件下,已开发出亚磺酸钠和2 H-吲唑之间的直接交叉偶联.在恒定电流为7 Ma的不分隔电池中利用石墨阳极和铂阴极可以使亚磺酸盐和2 H-吲唑同时氧化为磺酰基和自由基阳离子2 H-吲唑,从而促进了自由基与自由基的直接偶联反应反应生成3-磺酰化的2 H-吲唑衍生物.不含过渡金属和氧化还原试剂的合成方法应作为实现杂芳族化合物的有价值的合成工具.
DOI:10.1021/acs.Orglett.0C02144

专利信息

专利号:WO-2025077857-A1
优先权日:2023-10-13
标题:Use of prmt5 inhibitor in treatment of tumors or cancers
发明人：YAO BING; GU XIAOHUI; MAO WEIFENG; ASWAD FRED JULLIEN; JOSEPH JAMES DAVID; LI MINGXI
权利人:SHANGHAI APEIRON THERAPEUTICS COMPANY LTD
摘要:The present disclosure describes a novel molecule having protein arginine methyltransferase 5 inhibitory activity, and methods for synthesis and use of a compound. Specifically, the present disclosure describes a compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof, and methods for synthesis and use of the compound.

专利号:WO-2010096722-A1
优先权日:2009-02-20
标题 :3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors
发明人：FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
权利人:TAKEDA PHARMACEUTICAL; FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
摘要:Claimed are intermediates in the synthesis of N-Arylmethyl-3-Oxo-2,3-dihydro- [1,2,4]triazolo[4,3-a]pyridine-6-carboxamides as well as a process (A) to arrive at 3-Oxo-2, 3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid. The triazolo[4,3-a]pyridine-6-carboxamides of formula (I) are used as soluble epoxide hydrolase inhibitors (sEH) having therapeutic effect in pathologic conditions such as hypertension, stroke, inflammatory processes, diabetes and a variety of cardiovascular diseases.

专利号:CN-115403494-A
优先权日:2022-06-09
标题 :A method for the synthesis of Î²-hydroxysulfone derivatives by oxygen-initiated difunctionalization of alkenes under mild conditions

专利号:US-2011021532-A1
优先权日:2008-04-22
标题 :Novel substituted heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：POWELL DAVID; LEBRUN MARIE-EVE; BHAT SATHESH; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

专利号:CN-115403494-B
优先权日:2022-06-09
标题:A method for the synthesis of Î²-hydroxysulfone derivatives by oxygen-initiated difunctionalization of olefins under mild conditions

专利号:CN-117946101-A
优先权日:2024-01-05
标题 :A kind of arylmethyl sulfone compound and its synthesis method

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合成参考文献

摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 280.
摘要:DiRocco, D. A.; Schultz, D. M., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 627.
摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 20.