CAS: 87-92-3; Dibutyl L-(+)-Tartrate

该化合物是硝酸的手性死板衍生物,其特点是其立体特性(2R,3R)配置,该化合物因其作为非对称合成中多功能的手性建筑块的作用而备受重视,特别是在制药和精化化学品方面,其二氢氧化物组和丁基酯脂质提高了有机溶液的溶解性,促进了其在催化和声学反应中的使用.硬立体化学确保了合成应用中的高度对等选择性,使其对建设复杂的分子结构有用.此外,在温和条件下,该化合物的稳定性允许与各种反应协议广泛兼容.该化合物通常用于用于手性辅助和骨合成的学术和工业研究.

结构式图片

相似化合物

13811-71-7 87-91-2 7554-28-1

上下游产品

CAS号87-69-4 酒石酸 | CAS号71-36-3 正丁醇 | CAS号622-00-4 L-酒石酸二苄酯 | CAS号2319-57-5 L-苏丁醇 | CAS号6295-06-3 乙醛酸正丁酯

合成工艺路线路线简述

  • 合成目标产物 L-(+)-Tartaric Acid Di-N-Butyl Ester 主要起始原料 Dibenzyl L-Tartrate And 1-Butanol
  • 87-69-4 + 71-36-3 = 87-92-3 + 105-75-9 + 6280-99-5
    反应条件:1.1 Catalysts: Molybdenum,Oxobis(8-Quinolinolato-N1,O8)- Solvents: 1-Butanol; 12 H,160 °C
    标题:Single-Site Molybdenum Catalyst For The Synthesis Of Fumarate
    作者:Jiang,Huifang; Et Al
    参考文献:Chemcatchem 日期:2019 卷标:11(17) 页码:4291-4296]

    87-69-4 + 71-36-3 = 87-92-3
    反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Toluene; 5 H,Reflux
    标题:Synthesis Of Butyl L-Tartrate
    作者:Wei,Yan; Et Al
    参考文献:Huaxue Gongchengshi 日期:2007 卷标:21(4) 页码:1-2]

    87-69-4 + 71-36-3 = 87-92-3
    反应条件:1.1 Catalysts: Palladium Chloride; 5 H,80 °C
    标题:Pdcl2-Catalyzed Esterification Of Carboxylic Acids And Transesterification Of Esters
    作者:Svirskii,K. S.; Et Al
    参考文献:Bashkirskii Khimicheskii Zhurnal 日期:2010 卷标:17(2) 页码:162-164]

    87-69-4 + 71-36-3 = 87-92-3
    反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Cyclohexane; Rt -> 100 °C; 6 H,100 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water
    标题:Biobased Plasticizers From Tartaric Acid: Synthesis And Effect Of Alkyl Chain Length On The Properties Of Poly(Vinyl Chloride)
    作者:Zhu,Huichao; Et Al
    参考文献:Acs Omega 日期:2021 卷标:6(20) 页码:13161-13169]

    133-37-9 + 71-36-3 = 87-92-3
    反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Cyclohexane; 5 H,Reflux
    标题:Synthesis And Application Of 2,3-Dihydroxybutanedioic Acid Esters As Efficient Additives In Methanol-Gasoline
    作者:Jiang,Xiaoyan; Et Al
    参考文献:Asian Journal Of Chemistry 日期:2013 卷标:25(15) 页码:8451-8454
Dibenzyl (2R,3R)-2,3-Dihydroxybutanedioate,正丁醇 以 Various Solvent(S) 作为反应溶剂,化学反应 24.0H,以86.2%的收率获得产物l-酒石酸二丁酯
参考文献:A Convenient Method For Enzymatic Benzyl-Alkyl Transesterification Under Mild Neutral Conditions
标题:A Convenient Method For Enzymatic Benzyl-Alkyl Transesterification Under Mild Neutral Conditions
摘要:Lipases From Candida Cylindracea And From Pseudomonas Fluorescens Efficiently Catalyse The Benzyl To Alkyl Transesterification In Organic Solvents Under Mild Conditions In Nearly Quantitative Yields.
DOI:10.1016/s0040-4020(01)89450-3

海关参考信息

专利信息


专利号:US-8178474-B1
优先权日:1999-04-21
标题 :Functionalised solid support for alpha-oxoaldehyde synthesis
发明人:MELNYK OLEG; FRUCHART JEAN-SEBASTIEN; BOUREL LINE; GRAS-MASSE HELENE
权利人:MELNYK OLEG; FRUCHART JEAN-SEBASTIEN; BOUREL LINE; GRAS-MASSE HELENE; PASTEUR INSTITUT; CENTRE NAT RECH SCIENT
摘要:The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one α-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a diagnostic reagent, of a microtitration plate and of a biochip, such as a DNA chip. The present invention also relates to a process for the synthesis of organic compounds comprising at least one α-oxoaldehyde function and to the α-oxoaldehyde peptides obtained using this process.

专利号:US-7812193-B2
优先权日:2003-09-19
标题:Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
发明人:REBIERE FRANCOIS; DURET GERARD; PRAT LAURENCE
权利人:CEPHALON FRANCE
摘要:The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of:n a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I); nn nwherein n, Y, R 1 , R 1a , R 2 and R 2a are as defined herein.

专利号:US-2023339839-A1
优先权日:2022-04-24
标题:Synthesis method of alpha-hydroxycarboxylic acid ester
发明人:MENG ZHONGLEI; QIN RONGXIU; GAO SHOUNA; HU GUOJIAO; WEN RUSI; Liao Zhongqiu; LIANG ZHONGYUN; HU LIHONG; ZHOU YONGHONG
权利人:GUANGXI FORESTRY RES INSTITUTE
摘要:A synthesis method of alpha-hydroxycarboxylic acid ester is provided. In the method, an alpha-hydroxycarboxylic acid and an alcohol are taken as raw materials, one or more of boric acid, metaboric acid, pyroboric acid, and boric anhydride is taken as a catalyst, and one of cyclohexane, toluene, benzene, and alcohols is taken as a water-carrying agent. A reaction temperature is kept in range of 100-160° C., produced water is separated by an oil-water separator, and the alpha-hydroxycarboxylic acid ester is synthesized directly. After an esterification reaction, the water-carrying agent and unreacted alcohol are distilled by vacuum fractionation to obtain a crude product, and refined alpha-hydroxycarboxylic acid ester is obtained by performing neutralization, water washing, and vacuum rectification on the crude product. The alpha-hydroxycarboxylic acid ester prepared by the method has high purity and light color, and can be used as green solvent, surfactant, chiral resolution agent and plasticizer.

专利号:US-2005222257-A1
优先权日:2003-09-19
标题:Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation

专利号:US-7317126-B2
优先权日:2003-09-19
标 题:Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation

专利号:CA-2538697-C
优先权日:2003-09-19
标 题 :Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
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主要参考文献


1: Chang CW, Chen YC, Liu CY. An investigation into the stability of microemulsions in electrophoresis. Electrophoresis. 2014 Oct;35(20):2901-6. doi: 10.1002/elps.201400250. Epub 2014 Sep 23. doi: 10.1002/elps.201200150. Epub 2012 Dec 18. doi: 10.1016/j.chroma.2009.09.036. Epub 2009 Sep 18. doi: 10.1016/j.chroma.2008.10.029. Epub 2008 Oct 14. Chinese.

合成参考文献


参考文献:10.1007/978-1-59745-376-9_29
摘要:Buchberger WW. Microemulsion electrokinetic chromatography. Methods Mol Biol. 2008;384():717–33. doi: 10.1007/978-1-59745-376-9_29.
参考文献:10.1007/978-1-62703-263-6_23
摘要:Borst C, Holzgrabe U. Cyclodextrin-mediated enantioseparation in microemulsion electrokinetic chromatography. Methods Mol Biol. 2013;970():363–75. doi: 10.1007/978-1-62703-263-6_23.
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2009).
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