CAS: 67330-25-0; Butyl 2-((3-(Trifluoromethyl)Phenyl)Amino)Benzoate

该化合物是一种化学化合物,被归类为非类固醇抗炎药物(NSAID),主要用于其止痛和抗炎性特性,使其有效治疗疼痛和炎症等症状.Ufenamate功能通过抑制环氧基酶(COX)酶(Cofenamate),在合成异丙酯,体内介质炎和疼痛反应中起着关键作用.该物质通常在热液配方中施用,允许局部治疗,减少系统副作用.Ufenamate的特点是水中的溶性相对较低,影响其配制和交付方法.安全性和功效剖面是其使用中的基本考虑因素,与任何药物一样,潜在副作用可能包括皮肤刺激或过敏反应.

结构式图片

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

氟灭酸 Flufenamic Acid 530-78-9

合成工艺路线路线简述

    📜Potassium; 2-(3-Trifluoromethyl-Phenylamino)-Benzoate,正溴丁烷 反应生成 氟灭酸丁酯
    参考文献:Kato,H.
    标题:Kato,H.

    海关参考信息

    专利信息


    专利号:US-9051302-B2
    优先权日:2008-01-15
    标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
    发明人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
    权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
    摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

    专利号:US-4778805-A
    优先权日:1987-06-18
    标题:4,7-benzofurandione derivatives useful as inhibitors of leukotriene synthesis
    发明人:ADAMS JULIAN; GUINDON YVAN; BELANGER PATRICE C; BELLEY MICHEL L; ROKACH JOSHUA
    权利人:MERCK FROSST CANADA
    摘要:4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention. ##STR1##

    专利号:US-10239856-B2
    优先权日:2008-01-15
    标题:Synthesis of resorcylic acid lactones useful as therapeutic agents

    专利号:CN-101990399-B
    优先权日:2008-01-15
    标 题:Synthesis of dihydroxybenzoic acid lactones as therapeutic agents

    专利号:US-2011217335-A1
    优先权日:2008-01-15
    标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents

    专利号:US-2016075677-A1
    优先权日:2008-01-15
    标 题:Synthesis of resorcylic acid lactones useful as therapeutic agents

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    1. Iino H, Fujii M, Fujino M, Kohara S, Hashizaki K, Kira H, Koizumi N, Watanabe Y, Utoguchi N. Influence of Characteristics of Oily Vehicle on Skin Penetration of Ufenamate. Biol Pharm Bull. 2017;40(2):220-226. doi: 10.1248/bpb.b16-00817. 38(10):1645-8. doi: 10.1248/bpb.b15-00267. 331(2):383-8. doi: 10.1016/0021-9673(85)80044-3.

    合成参考文献


    摘要:Drugs in Japan, -(160), 1990
    摘要:Drugs in Japan, -(197), 1995
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