CAS: 610-78-6; 4-Chloro-3-Nitrophenol

上下游产品

meta-nitrophenol tris(4-chlorophenyl) phosphate 4-hydroxy-2-nitroaniline 1-chloro-4-ethoxy-2-nitrobenzene 4,6-dichloro-1-hydroxy-3-aminobenzene 3-amino-4-chlorophenol 4-chloro-3-nitrophenyl acetate Is°Chlorthion

4-氯-3-硝基苯甲醚置于三溴化硼体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 4-氯-3-硝基苯酚
参考文献:基于 3D-Qsar 的分子设计发现超高活性 N-苯基吡唑作为候选杀虫剂
标题:基于 3D-Qsar 的分子设计发现超高活性 N-苯基吡唑作为候选杀虫剂
摘要:三维定量构效关系(3D-Qsar)是指导新农药开发中分子设计的最重要和最有效的工具之一.chlorantraniliprole 是一种邻氨基苯甲酸二酰胺兰尼碱受体 (Ryr) 激动剂,具有超高活性,高选择性和哺乳动物安全性.为了继续我们对新杀虫剂开发的研究,在这里,我们以氯虫苯甲酰胺类似物的 3D-Qsar 为指导,设计了新的杀虫剂n-苯基吡唑.大多数合成的目标化合物对mythimna Separata,Plutella Xylostella和spodoptera Frugiperda表现出中等到极好的活性.化合物iii B和iii Y对m. Separata显示出与氯虫苯甲酰胺相似的活性(lc 50值:分别为 0.21,0.25 和 0.16 μg Ml-1).化合物iii B对小菜蛾的效力比氯虫苯甲酰胺高 3 倍.对于s. Frugiperda,Iii A和iii B的效力分别比阳性对照高
DOI:10.1021/acs.Jafc.2C08719

专利信息

专利号:US-8372380-B2
优先权日:2007-03-30
标 题:In vivo imaging of sulfotransferases
发明人：BARRIO JORGE R; KEPE VLADIMIR; SMALL GARY W; SATYAMURTHY NAGICHETTIAR
权利人:UNIV CALIFORNIA; BARRIO JORGE R; KEPE VLADIMIR; SMALL GARY W; SATYAMURTHY NAGICHETTIAR
摘要:Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled with 18 F, 123 I, 124 I, 125 I, or 11 C. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.

专利号:CN-110156712-A
优先权日:2019-04-25
标 题 :A kind of synthesis of benzoxazole compounds and its application by utilizing aromatic hydrocarbon nitration by-products

专利号:US-5670667-A
优先权日:1995-07-25
标题 :Chroman-2-ylmethylamino derivatives
发明人：MEWSHAW RICHARD E
权利人:AMERICAN HOME PROD
摘要:Compounds of the formula: I in which Z is hydrogen or a halogen; n is one of the integers 1, 2, 3, or 4; m is one of the integers 0 or 1; R is a substituted or unsubstituted aryl group in which the substituents are, independently, one or two members selected from the group consisting of alkyl, hydroxy, halo or amino groups; R2 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof, are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analagous drugs.

专利号:US-5817690-A
优先权日:1996-08-27
标 题:4-aminoethoxy indolone derivatives
发明人：MEWSHAW RICHARD ERIC
权利人:AMERICAN HOME PROD
摘要:A compound of the formula I: I in which Y is hydrogen, halogen or lower alkoxy; R1 is hydrogen, lower alkyl or aryl(lower)alkyl; R2 is hydrogen, lower alkyl or -(CH2)nXpAr, where X is oxygen or carbonyl; Ar is cycloalkyl, aryl or arylaryl, oxindolyl, benzimidazolyl, indolyl, 2-oxobenzimidazolyl or 2-thioxobenzimidazolyl; or R1 and R2, taken together with the nitrogen atom to which they are attached, complete a 3,4-dihydro-1H-isoquinolinyl or 1,3-dihydro-isoindolyl; n is one of the integers 1,2,3,4,5 or 6; p is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.

专利号:US-5958965-A
优先权日:1996-08-27
标 题 :4-aminoethoxy indoles
发明人：MEWSHAW RICHARD ERIC; WEBB MICHAEL BYRON
权利人:AMERICAN HOME PROD
摘要:Compounds of the formula: in which R1 is hydrogen, alkyl, cycloalkylalkyl, arylalkyl, (haloaryl)alkyl, (alkoxyaryl)alkyl, thienylmethyl, furanylmethyl, pyridinylmethyl, alkylphenyl, 4-fluorobutyrophenone or 6-fluoro-1,2-benzisoxazol-yl-propyl; X is hydrogen, halogen, cyano, alkyl, acetyl, trifluoroacetyl, trifluoromethyl or formyl; Y is hydrogen, halogen, alkoxy or alkyl; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analagous drugs and they also have affinity for the 5-HT1A receptors which characterizes them as useful in the treatment of diseases attending disturbances in the serotinergic systems, such as anxiety, stress, depression, sexual dysfunctions and sleep disturbances.

专利号:EP-0923551-B1
优先权日:1996-08-27
标题:4-aminoethoxy indolone derivatives
发明人：MEWSHAW RICHARD ERIC
权利人:AMERICAN HOME PROD
摘要:A compound of formula (I) in which Y is hydrogen, halogen or lower alkoxy; R1 is hydrogen, lower alkyl or aryl(lower)alkyl; R2 is hydrogen, lower alkyl or -(CH2)nXpAr, where X is oxygen or carbonyl; Ar is cycloalkyl, aryl or arylaryl, oxindolyl, benzimidazolyl, indolyl, 2-oxobenzimidazolyl or 2-thioxobenzimidazolyl; or R1 and R2, taken together with the nitrogen atom to which they are attached, complete a 3,4-dihydro-1H-isoquinolinyl or 1,3-dihydro-isoindolyl; n is one of the integers 1,2,3,4,5 or 6; p is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.