专利号:US-7247752-B2 优先权日:2004-10-01 标 题 :Methods for the synthesis of astaxanthin 发明人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID 权利人:CARDAX PHARMACEUTICALS INC 摘要:A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.
专利号:US-7435861-B2 优先权日:2005-04-29 标 题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates 发明人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID 权利人:CARDAX PHARMACEUTICALS INC 摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
专利号:US-2008221377-A1 优先权日:2006-06-16 标题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates 发明人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L 权利人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L 摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
专利号:US-4814347-A 优先权日:1985-07-22 标 题:Anthelmintic spiroketals and method of use 发明人:NELSON STEPHEN J 权利人:UPJOHN CO 摘要:This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.
专利号:US-8288566-B2 优先权日:2008-11-17 标 题 :Enantioselective synthesis of γ-amino-αβ-unsaturated carboxylic acid derivatives 发明人:ACEMOGLU MURAT; PFALTZ ANDREAS; SCHAERER CLAUDE 权利人:ACEMOGLU MURAT; PFALTZ ANDREAS; SCHAERER CLAUDE; NOVARTIS AG 摘要:Provided is an enantioselective, palladium-catalyzed method for the preparation of γ-amino-α,β-unsaturated carboxylic acid derivatives having the formulas II, III, VII and VIII:
专利号:US-10344009-B2 优先权日:2015-11-03 标题 :Process for the preparation of sofosbuvir 发明人:JAYACHANDRA SURESHBABU; KAUSHIK VIPIN KUMAR; RAVI VIJAYA KRISHNA; DEV VIKAS CHANDRA; KOTTOLLA SAIPRASAD; RAO POTLA VENKATA SRINIVASA; VAKITI SRINIVAS; MUGGU CHAITANYA; DANDALA SUBRAMANYAM 权利人:MYLAN LABORATORIES LTD 摘要:A process for the preparation of intermediates 9, useful in the synthesis of sofosbuvir, as well as intermediates of formula [12] are disclosed herein.
摘要:Abell, A. D.; Edmonds, M. K., Science of Synthesis, (2009) 46, 25. 摘要:Abell, A. D.; Edmonds, M. K., Science of Synthesis, (2009) 46, 35. 摘要:Koo, S., Science of Synthesis, (2010) 45, 1370. 摘要:Yliniemelä-Sipari, S. M.; Piisola, A.; Pihko, P. M., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 59. 摘要:Fleischer, I.; Mejía, E., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 152.