CAS: 56701-24-7; Dl-Vestitol

该化合物是一种苯丙丙烯衍生物,具有替代苯基组,由于其结构特征而具有潜在的生物活动潜力;氢氧基和甲基氧功能组的存在增强了其溶性和回活动性,使之适合于医药化学和有机合成的应用;二氢苯并呋喃核心提供了稳定性,同时允许进一步发挥功能;该化合物可作为制药的中间体,特别是在氟氯类或相关生物活性分子的合成中;其界定的结构和纯度确保了研究和工业应用的再生性.

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物理性质

MSDS等安全信息

上下游产品

4-benzyloxy-salicylalcohol (+/-)-vestitol diacetate

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    专利信息


    专利号:US-10030003-B2
    优先权日:2014-09-10
    标 题:Synthesis of isoflavanes and intermediates thereof
    发明人：BELIAEV NIKOLAI; SHAFRAN YURI
    权利人:SYSTEM BIOLOGIE AG
    摘要:Subject of the invention is a method for enantioselective production of an isoflavane from an isoflavone, comprising the steps: (a) selectively reducing the isoflavone, such that the 4-keto group of the isoflavone is converted to a 4-hydroxy group, and the 2,3-double bond of the isoflavone is converted to a 2,3-single bond, thereby obtaining a 4-hydroxy intermediate, and (b) reacting the 4-hydroxy intermediate with a chiral reagent, such that a chiral group is covalently attached to the C4-position of the 4-hydroxy intermediate, thereby obtaining a chiral intermediate. The invention also relates to intermediates of formulae (IV), (V), (VI) and (VII) obtainable in the inventive process.

    专利号:US-8969596-B2
    优先权日:2008-08-14
    标题:Synthesis of equol
    发明人：STEFFAN BERT
    权利人:STEFFAN BERT
    摘要:Subject of the invention is a method for the production of isoflavanes from isoflavones, whereby in a first reaction step (a) the 4-keto group of the isoflavone is reduced in a enantioselective manner, whilst the 2,3-double bond is maintained, to the 4-hydroxy compound.

    专利号:US-2012094336-A1
    优先权日:2008-08-14
    标题:Synthesis of equol

    专利号:CA-2960437-A1
    优先权日:2014-09-10
    标 题 :Synthesis of isoflavanes and intermediates thereof

    专利号:US-2017283389-A1
    优先权日:2014-09-10
    标题 :Synthesis of Isoflavanes and Intermediates Thereof

    专利号:KR-20170054461-A
    优先权日:2014-09-10
    标 题 :Synthesis of isoflavanes and intermediates thereof

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    主要参考文献

    参考标题: Synthesis Of Isoflavanes And Intermediates Thereof Synthèse D'Isoflavones Et Intermédiaires De Celles-Ci
    摘要:Subject Of The Invention Is A Method For Enantioselective Production Of An Isoflavane From An Isoflavone, Comprising The Steps: (A) Selectively Reducing The Isoflavone, Such That The 4-Keto Group Of The Isoflavone Is Converted To A 4-Hydroxy Group, And The 2,3-Double Bond Of The Isoflavone Is Converted To A 2,3-Single Bond, Thereby Obtaining A 4-Hydroxy Intermediate, And (B) Reacting The 4-Hydroxy Intermediate With A Chiral Reagent, Such That A Chiral Group Is Covalently Attached To The C4-Position Of The 4-Hydroxy Intermediate, Thereby Obtaining A Chiral Intermediate. The Invention Also Relates To Intermediates Of Formulae (Iv), (V), (Vi) And (Vii) Obtainable In The Inventive Process.

    合成参考文献


    参考文献:10.1016/0305-1978(93)90090-e
    摘要:Kajiyama K, Hiraga Y, Takahashi K, Hirata S, Kobayashi S, Sankawa U, Kinoshita T. Flavonoids and isoflavonoids of chemotaxonomic significance from Glycyrrhiza pallidiflora (Leguminosae). Biochemical Systematics and Ecology. 1993 Dec;21(8):785–93. doi: 10.1016/0305-1978(93)90090-e.
    参考文献:10.1124/mol.119.115964
    摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
    参考文献:10.1271/bbb.100285
    摘要:UEDA H, SUGIMOTO Y. Vestitol as a Chemical Barrier against Intrusion of Parasitic PlantStriga hermonthicaintoLotus japonicusRoots. Bioscience, Biotechnology, and Biochemistry. 2010 Aug 23;74(8):1662–7. doi: 10.1271/bbb.100285.
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