CAS: 498-94-2; Piperidine-4-Carboxylic Acid

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5984-56-5 10314-98-4 148928-15-8

上下游产品

CAS号13602-12-5 异烟酸-N-氧化物 | CAS号55-22-1 异烟酸 | CAS号3731-38-2 3-奎宁环酮 | CAS号10314-98-4 N-Cbz-哌啶-4-羧酸 | CAS号857778-39-3 4-bromo-2-(2-br... | CAS号110-89-4 六氢吡啶 | CAS号64-18-6 甲酸 | CAS号6238-69-3 NITROSOISONIPEC... | CAS号1219594-56-5 1-[bis(dimethyl... | CAS号5398-44-7 2,6-二氯吡啶-4-甲酸 | CAS号101264-48-6 4-(苯基甲基氨基羰基)哌啶 | CAS号71985-80-3 1-甲基哌啶-4-甲酸盐酸 | CAS号50675-21-3 1-甲基哌啶-4-甲醛 | CAS号5274-99-7 1-苯甲酰哌啶-4-羧酸 | CAS号55745-83-0 2-哌嗪-1-基-1,3-苯并噻唑 | CAS号30818-11-2 1-哌啶-4-乙酮 | CAS号55695-51-7 4-(4-氯苯甲酰基)哌啶盐酸盐 | CAS号92822-02-1 4-(4'-氟苄基)哌啶 | CAS号51784-73-7 2-(4-哌啶基)-1,3-苯并噻唑 | CAS号51784-03-3 2-哌啶-4-苯并噁唑

3-奎宁环酮置于双氧水体系中,用 乙醇 作为反应溶剂,化学反应 2.0H,以72%的收率获得产物4-哌啶甲酸
参考文献:α-(n,N-二烷基)氨基酮的过氧化氢氧化
标题:α-(n,N-二烷基)氨基酮的过氧化氢氧化
摘要:α-(n,N-二烷基)氨基酮被过氧化氢氧化裂解,反应生成羧酸和衍生自亚胺鎓中间体的产物.
DOI:10.1039/c39830000392

专利信息

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-8697876-B2
优先权日:2010-04-02
标 题:Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists
发明人：CARNIAUX JEAN-FRANCOIS; CUMMINS JONATHAN
权利人:CARNIAUX JEAN-FRANCOIS; CUMMINS JONATHAN; COLUCID PHARMACEUTICALS INC
摘要:The present invention provides a novel polymorph of the hemisuccinate salt of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide (Form A) characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure. This polymorph is useful in pharmaceutical compositions, for example, for the treatment and prevention of migraine. The invention also provides a process for the synthesis of pyridinoylpiperidine compounds of Formula I in high yield and high purity. In particular, the provides a process for the preparation of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide, its hemisuccinate salt and polymorph (Form A).

专利号:US-7524963-B2
优先权日:2001-10-15
标题:Synthesis of (4-bromophenyl)(4-piperidyl)methanone-(Z)-O-ethyloxime and salts
发明人：WONG GEORGE S K; PARK JEONGHAN; TONG WEIDONG; RAGHAVAN RAMANI R
权利人:SCHERING CORP
摘要:In one embodiment, the present invention describes the synthesis of (4-bromophenyl) (4-piperidyl)methanone-(Z)-O-ethyloxime and its acid salts, and similar compounds, in high stereochemical purity.

专利号:US-9475837-B2
优先权日:2011-12-23
标题 :Process for the synthesis of therapeutic peptides
发明人：HURLEY FIONN; WEGNER KATARZYNA; FOLEY PATRICK
权利人:IPSEN MFG IRELAND LTD
摘要:The present invention relates to a process for the large-scale synthesis of therapeutic peptides using a Sieber Amide resin, which comprises solid-phase Fmoc-chemistry.

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.