CAS: 379231-04-6; N-(5-Chlorobenzo[d][1,3]Dioxol-4-yl)-7-(2-(4-Methylpiperazin-1-yl)Ethoxy)-5-((Tetrahydro-2H-Pyran-4-yl)Oxy)Quinazolin-4-Amine

专利信息

专利号:US-2024400576-A1
优先权日:2021-09-03
标 题:Nitrogen-containing derivatives of salinomycin, synthesis and uses thereof
发明人：RODRIGUEZ RAPHAËL; CZERWONKA DOMINIKA; ANTOSZCZAK MICHAL; HUCZYNSKI ADAM
权利人:CENTRE NAT RECH SCIENT; INST CURIE; INST NAT SANTE RECH MED; ADAM MICKIEWICZ UNIV
摘要:The present invention relates to nitrogen-containing derivatives of salinomycin having the formula (I), as well as pharmaceutically acceptable salt thereof, and synthesis and uses thereof, in particular for the treatment and/or prevention of cancer including for preventing cancer metastasis and/or for preventing cancer recurrence and/or for decreasing resistance to a chemotherapy in a subject.

专利号:US-2025250280-A1
优先权日:2021-09-03
标 题 :Nitrogen-containing derivatives of narasin, synthesis and uses thereof
发明人：RODRIGUEZ RAPHAËL; CAÑEQUE TATIANA; MÃœLLER SEBASTIAN; ANTOSZCZAK MICHAL
权利人:CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; INST CURIE
摘要:The present invention relates to nitrogen-containing derivatives of narasin having the formula (I), as well as synthesis and uses thereof, in particular for the treatment and/or prevention of cancer. Also disclosed are medicaments including the nitrogen-containing derivatives of narasin, which include medicaments for preventing cancer metastasis and/or for preventing cancer recurrence and/or for decreasing resistance to a chemotherapy in a subject.

专利号:US-2024360247-A1
优先权日:2021-08-10
标 题:Compositions and methods for treatment of cancer
发明人：CHATTERJEE SUBROTO
权利人:UNIV JOHNS HOPKINS
摘要:Compositions in the prevention and treatment of cancers, such as colorectal cancer or diseases associated with abnormal levels of β-1,4-galactosyltransferase-V (β-1,4-GalT-V), include at least one inhibitor of glycosphingolipid synthesis.

专利号:US-11781178-B2
优先权日:2017-12-15
标题:Methods and compositions for the amplification of mRNA
发明人：DECKER WILLIAM K; KONDURI VANAJA
权利人:BAYLOR COLLEGE MEDICINE
摘要:Provided herein are compositions and methods for the synthesis, amplification, and in vitro transcription of full-length cDNA, or cDNA fragments. Methods are provided for reverse transcription of RNA and amplification for in vitro transcription. Further provided are method for loading of dendritic cells with the RNA and homologous lysate for immune stimulation.

专利号:WO-2024117980-A1
优先权日:2022-12-02
标题 :Compounds for modulating src family kinases and uses thereof
发明人：KUMAR ALAN PREM; SETHI GAUTAM; LEE E HUI CLARISSA; - BASAPPA; RANGAPPA KANCHUGARAKOPPAL S; MOHAN CHAKRABHAVI DHANANJAYA
权利人:NAT UNIV SINGAPORE; UNIV OF MYSORE
摘要:The present invention relates to chalcone (CHL) compounds, their synthesis, and applications in modulating the activity of Src Family Kinases (SFKs), specifically Lyn kinase, and methods of use in treating various diseases and conditions associated with aberrant activity of Src Family Kinases.

专利号:US-9295731-B2
优先权日:2013-04-01
标题 :Cleavable drug conjugates, compositions thereof and methods of use
发明人：NGUYEN MARK QUANG
权利人:NGUYEN MARK QUANG
摘要:Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.