CAS: 376608-75-2; 2-(((3Ar,4S,6R,6As)-6-(7-Chloro-5-(Propylthio)-3H-[1,2,3]Triazolo[4,5-D]Pyrimidin-3-yl)-2,2-Dimethyltetrahydro-3Ah-Cyclopenta[d][1,3]Dioxol-4-yl)Oxy)Ethanol

相似化合物

220241-61-2 2435586-21-1 376608-75-2

上下游产品

2-[((3aR,4S,6R,6aS)-6-[[5-amino-6-chloro-2-(propylsulfanyl)-4-pyrimidinyl]amino]-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy]-1-ethanol 4,6-dihydroxy-2-(propylsulfanyl)pyrimidine 4,6-dihydroxy-5-nitro-2-(propylthio)pyrimidine 4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine [3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol

(3Ar,4S,6R,6As)-6-Amino-2,2-Dimethyltetrahydro-3Ah-Cyclopenta-[d][1,3]Dioxol-4-Ol D-(-)-Mandelate置于palladium On Activated Charcoal Potassium Tert-Butylate,氢气,Potassium Carbonate,亚硝酸异戊酯体系中,用 乙醇,水,4-甲基-2-戊酮,乙腈 用作溶剂,化学反应生成2-[[(3Ar,4S,6R,6As)-6-[7-氯-5-(丙硫基)-3H-1,2,3-三氮唑并[4,5-D]嘧啶-3-基]四氢-2,2-二甲基-4H-环戊烯并-1,3-二恶茂-4-基]氧基]乙醇
参考文献: Optically Active Salts Of (3Ar,4S,6R,6As)-6-Amino-2,2-Dimethyltetrahydro-3Ah-Cyclopenta-[d] [1,3]Dioxol-4-Ol And A Method Of Their Preparation[fr] Sels Optiquement Actifs De (3Ar,4S,6R,6As)-6-Amino-2,2-Diméthyltétrahydro-3Ah-Cyclopenta-[d] [1,3]Dioxol-4-Ol Et Procédé Pour Leur Préparation
标题: Optically Active Salts Of (3Ar,4S,6R,6As)-6-Amino-2,2-Dimethyltetrahydro-3Ah-Cyclopenta-[d] [1,3]Dioxol-4-Ol And A Method Of Their Preparation[fr] Sels Optiquement Actifs De (3Ar,4S,6R,6As)-6-Amino-2,2-Diméthyltétrahydro-3Ah-Cyclopenta-[d] [1,3]Dioxol-4-Ol Et Procédé Pour Leur Préparation
摘要:化合物i与d-(-)-苹果酸和r-(-)-3-氯苹果酸的非对映异构体盐,其制备方法及其在药物替卡格雷洛的合成中的应用.

专利信息

专利号:US-9469614-B2
优先权日:2011-10-27
标 题:Synthesis of triazolopyrimidine compounds
发明人：ZUPANCIC BORUT; MARAS NENAD; STERK DAMJAN
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives.

专利号:EP-2607355-A1
优先权日:2011-12-23
标 题:Synthesis of triazolopyrimidine compounds
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-9278972-B2
优先权日:2011-12-23
标题 :Synthesis of triazolopyrimidine compounds
发明人：MARAS NENAD; GAZIC SMILOVIC IVANA; STERK DAMJAN
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-9221829-B2
优先权日:2011-09-14
标题:Synthesis of triazolopyrimidine compounds
发明人：MARAS NENED; ZUPANCIC BORUT
权利人:MARAS NENED; ZUPANCIC BORUT; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives, suitable for the preparation of Ticagrelor (TCG).

专利号:EP-2570405-A1
优先权日:2011-09-14
标题:Synthesis of Triazolopyrimidine Compounds
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the filed of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives, suitable for the preparation of ticagrelor (TGC)

专利号:EP-2586773-A1
优先权日:2011-10-27
标题 :Synthesis of Triazolopyrimidine Compounds
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives.