CAS: 31868-18-5; 10-Chloro-11B-(2-Chlorophenyl)-3-Methyl-2,3,5,7-Tetrahydro-[1,3]Oxazolo[3,2-D][1,4]Benzodiazepin-6-One

上下游产品

2-Amino-1-propanol 2-(2-bromo-acetylamino)-5,2'-dichloro-benzophenone

📜7-Chloro-5-(2-Chloro-Phenyl)-4-(2-Hydroxy-1-Methyl-Ethyl)-2-Oxo-2,3-Dihydro-1H-Benzo[e][1,4]Diazepin-4-Ium置于borate Buffer (Ph=8-10.5)体系中,用 乙醇,水 作为反应溶剂,化学反应生成 美沙唑仑
参考文献:The Acid-Base Equilibrium Reaction Of Benzodiazepinooxazoles.
标题:The Acid-Base Equilibrium Reaction Of Benzodiazepinooxazoles.
摘要:研究了恶唑仑(10-氯-2,3,5,6,7,11B-Hexahydro-2-Methyl-11B-Phenylbenzo [6,7]-1,4-Diazepino [5,4-B] Oxazol-6-One)和 1,4-苯并二氮杂卓(bdoz)的 13 种其他衍生物的酸碱平衡反应.研究采用紫外吸收光谱和荧光光谱来获得平衡常数.在大多数 Bdoz 中,质子化的物质会在与二氮杂卓核融合的恶唑烷环上迅速裂解,并与原始物质达到平衡.少数特殊化合物的平衡需要明显的时间差.从物理有机化学的角度讨论了取代基对 Pka 值的影响.
DOI:10.1248/cpb.30.3810

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

专利号:US-2016046560-A1
优先权日:2013-04-05
标题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same

专利号:WO-2014165816-A1
优先权日:2013-04-05
标 题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same

专利号:US-6884842-B2
优先权日:1997-10-14
标题:Molecular compounds having complementary surfaces to targets
发明人：SOANE DAVID S; BARRY STEPHEN E; GOODWIN ANDREW; OFFORD DAVID A; PERROTT MICHAEL G
权利人:ALNIS BIOSCIENCES INC
摘要:Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs may have surfaces that include functional groups that are complementary to surface sites of targets such as nanostructures or macromolecular targets, and may be capable of specifically interacting with such targets. The positions of the functional groups in one embodiment are stabilized by a polymer network. The SPCs are formed by contacting the target with a set of monomers which self-assemble on the target, and then are polymerized into a network to form the synthetic polymer complement. At least a portion of the surface of the resulting SPC thus may include an imprint of the target. The complex of the SPC and the target may be the desired product. Alternatively, the target is released, for example, by controllably expanding and contracting the crosslinked network. The SPC is isolated and used in many applications.