CAS: 287930-73-8; 4-Benzyl-2-Hydroxymorpholin-3-One

上下游产品

CAS号110843-90-8 4-苄基吗啉-2,3-二酮 | CAS号298-12-4 乙醛酸 | CAS号104-63-2 N-苄氨基乙醇 | CAS号563-96-2 乙醛酸,一水 | CAS号109745-70-2 methyl 2-(hydro... | CAS号108228-02-0 methyl 2-methox... | CAS号171338-27-5 (2R,3S)-2-[(1R)... | CAS号287930-75-0 (2R)-4-苄基-2-[(1... | CAS号170729-80-3 阿瑞吡坦

N-苄基乙醇胺置于l-Selectride体系中,化学反应生成4-苄基-2-羟基-吗啉-3-酮
参考文献:吗啉-2,3-二酮和2-羟基吗啉-3-酮的合成:阿瑞匹坦的中间体
标题:吗啉-2,3-二酮和2-羟基吗啉-3-酮的合成:阿瑞匹坦的中间体
摘要:据报道,由n-取代的β-氨基醇制备吗啉-2,3-二酮和2-羟基吗啉-3-酮.这些是阿瑞吡坦合成和开发中有用的中间体.
Doi:10.1016/j.Tetlet.2004.09.185

专利信息

专利号:US-6600040-B2
优先权日:2000-06-08
标 题:Process for the synthesis of (2R, 2-alpha-R, 3A)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1, 4-oxazine
发明人：BRANDS KAREL M JOS; TSAY FUH-RONG; CONRAD KAREN M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6395898-B1
优先权日:2000-06-09
标 题:Trans-glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
发明人：MCNAMARA JAMES M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6469164-B2
优先权日:2000-06-08
标题:Process for the synthesis of (2R, 2-alpha-R)-4-benzyl-2-[1-(3,5-bis (trifluoromethyl)phenyl)ethoxy]-1,4-oxazine-3-one
发明人：BRANDS KAREL M JOS; PAYACK JOSEPH F; PYE PHILIP J
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-1,4-oxazin-3-one. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6538134-B2
优先权日:2000-06-08
标 题 :4-Benzyl-2-hydroxy-1,4-oxazine-3-one and polymorphic forms thereof
发明人：CROCKER LOUIS S; BRANDS KAREL M JOS; NELSON TODD D; PYE PHILIP J; ROSEN JONATHAN D; ROSSEN KAI
权利人:MERCK & CO INC
摘要:The present invention is concerned with 4-benzyl-2-hydroxy-1,4-oxazin-3-one, and novel processes for the preparation therof. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-2002022725-A1
优先权日:2000-06-09
标 题 :Trans-glycosidation process for the synthesis of (2R, 2-alpha-R, 3a) -2-(1- (3,5-bis(trifluoromethyl) phenyl) ethoxy ) -3- (4-fluorophenyl) -1, 4-oxazine

专利号:US-2002052493-A1
优先权日:2000-06-08
标题:Process for the synthesis of (2R, 2-alpha-R) -4-benzyl-2-[1- (3,5-bis (trifluoromethyl) phenyl) ethoxy] -1,4-oxazine-3-one