CAS: 28697-53-2; (3S,4R,5R)-Tetrahydro-2H-Pyran-2,3,4,5-Tetraol

上下游产品

diazomethane 2)-3)>-β-D-glucuronopyranosyl quillaic acid 28-O-β-D-apiofuranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-3)>-α-L-rhamnopyranosyl-(1->2)-β-D-fucopyranoside.3-O-β-D-galactopyranosyl-(1-2)-β-D-xylopyranosyl-(1-3)-β-D-glucuronopyranosyl quillaic acid 28-O-β-D-apiofuranosyl-(1-3)-β-D-xylopyranosyl-(1-4)-β-D-glucopyranosyl-(1-3)-α-L-rhamnopyranosyl-(1-2)-β-D-fucopyranoside. methanol D-(+)-xylobiosemethyl xyloside methyl-β-D-xylopyranoside methyl-α-D-xylopyranoside (2R,3R,4S)-5-[(4,5-Diphenyl-oxazol-2-yl)-hydrazono]-pentane-1,2,3,4-tetraol

D-甘露糖-1,4-内酯置于氧气,Lithium Hydroxide,10-甲基-9-均三甲苯基吖啶高氯酸盐体系中,用 水,乙腈 用作溶剂,化学反应 18.0H,以41%的收率获得d-阿拉伯糖
参考文献:Degradation Of Unprotected Aldohexonic Acids To Aldopentoses Promoted By Light And Oxygen
标题:Degradation Of Unprotected Aldohexonic Acids To Aldopentoses Promoted By Light And Oxygen
摘要:Herein Reported Is A Photoredox-Catalyzed Oxidative Degradation Reaction Of Unprotected Aldohexonic Acids,Which Are Shortened By One-Carbon To The Corresponding Aldopentoses. Oxygen Including Aerial Oxygen Is Used As A Terminal Oxidant. The Mild Reaction Conditions Permit Even Disaccharides To Successfully Undergo The Degradation Reaction With The Glycosidic Bond Remaining Intact. Quinic Acid Is Also Converted To A Useful Chiral Synthetic Intermediate.
Doi:10.1246/cl.200517

专利信息

专利号:US-8263755-B2
优先权日:2006-11-20
标题:Synthesis of compounds useful as modulators of amyloid-beta production
发明人：FINDEIS MARK A
权利人:FINDEIS MARK A; SATORI PHARMACEUTICALS INC
摘要:As described herein, the present invention provides methods for preparing compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.

专利号:US-2024117398-A1
优先权日:2021-01-20
标 题:Production of oligosaccharides comprising ln3 as core structure in host cells
发明人：AESAERT SOFIE; BEAUPREZ JOERI; PETERS GERT; VERCAUTEREN ANNELIES
权利人:INBIOSE NV
摘要:Described is a method of producing an oligosaccharide comprising a lacto-N-triose (LN3; GlcNAc-beta1,3-Gal-beta1,4-Glc) as a core trisaccharide by cultivation with a genetically modified cell, as well as the genetically modified cell used in the method. The genetically modified cell comprises at least one nucleic acid sequence coding for a galactoside beta-1,3-N-acetylglucosaminyltransferase and a glycosyltransferase involved in the synthesis of an oligosaccharide comprising LN3 as a core trisaccharide and at least one nucleic acid sequence expressing a membrane protein. Furthermore, the present invention provides for a purification of the oligosaccharide comprising LN3 as a core trisaccharide from the cultivation.

专利号:US-8778689-B1
优先权日:2007-05-23
标题:Synthesis and use of chiral ionic liquids
发明人：SINGH GURDIAL; PLAZA PATRICE G J; BHONGADE BHOOMENDRA A
权利人:SINGH GURDIAL; PLAZA PATRICE G J; BHONGADE BHOOMENDRA A; UNIV THE WEST INDIES
摘要:We disclose the synthesis and use of chiral ionic liquids based on a substituted pentose, furanose, hexose, or pyranose sugar. The compounds and processes to make or use them are provided.

专利号:US-2024191270-A1
优先权日:2021-04-16
标 题 :Fermentative production
发明人：BEAUPREZ JOERI; COUSSEMENT PIETER; DECOENE THOMAS
权利人:INBIOSE NV
摘要:The present invention is in the technical field of synthetic biology and metabolic engineering. More particularly, the present invention is in the technical field of metabolically engineered cells and use of said cell in a cultivation, preferably a fermentation. The present invention describes a cell for the production of a compound. The cell comprises a pathway for the production of the compound, which can be a disaccharide, oligosaccharide and/or a Neu(n)Ac-containing bioproduct, wherein (n) is 4, 5, 7, 8 or 9 or a combination thereof. The cell is metabolically engineered for enhanced synthesis of acetyl-Coenzyme A. The invention also resides in a method of producing such compound by cultivation, preferably a fermentation, with such a cell.

专利号:US-2022403431-A1
优先权日:2020-02-14
标 题 :Glycominimized bacterial host cells
发明人：BEAUPREZ JOERI; DE MAESENEIRE SOFIA; SNOECK NICO
权利人:INBIOSE NV
摘要:This disclosure is in the technical field of synthetic biology and metabolic engineering. The disclosure provides engineered viable bacteria having a reduced or abolished synthesis of poly-N-acetyl-glucosamine (PNAG), Enterobacterial Common Antigen (ECA), cellulose, colanic acid, core oligosaccharides, Osmoregulated Periplasmic Glucans and Glucosylglycerol (O), glycan, and trebalose. The disclosure further provides methods for the production of bioproduct by the viable bacteria and uses thereof. Furthermore, the disclosure is in the technical field of fermentation of metabolically engineered microorganisms producing bioproduct.

专利号:EP-4520765-A1
优先权日:2023-09-08
标题:Ionizable cationic lipids incorporating silicon
发明人：RÉPà SI JÓZSEF; SZILVà GYI Gà BOR
权利人:ALDEXCHEM KFT
摘要:The present invention belongs to the field of biomedicine and drug delivery as well as pest and vector controls.The invention relates to a novel ionizable cationic lipid family incorporating silicon, which belongs to the trademark LipexSil^â„¢ 2^nd generation lipids, wherein the tail is connected to the headgroup with biodegradable silyl acetal linker. Lipids containing silyl acetal linker(s) are state-of-the-art and are effective as ionizable cationic lipids in the formulation of empty or loaded lipid nanoparticles (LNPs). The novel linkers according to the invention are designed by means of proprietary borane catalysts [WO 2022/129966]. The invention describes the synthesis of the lipids of formula (I), formation and characterization of nanoparticles and biological experiments demonstrating that the lipid nanoparticles prepared with these novel lipids can efficiently deliver their cargo (e.g. RNA, DNA, mRNA, siRNA, dsRNA, pDNA, circular DNA, small biologically active molecules) into the cells.