CAS: 270062-99-2; (S)-2-(2-(((9H-Fluoren-9-yl)Methoxy)Carbonyl)-1,2,3,4-Tetrahydroisoquinolin-3-yl)Acetic Acid

相似化合物

332064-67-2 332064-64-9 130309-33-0

上下游产品

formaldehyd (S)-3-(9H-fluoren-9-yl)methoxycarbonylamino-4-phenylbutanoic acid

📜聚合甲醛,Fmoc-L-Beta-高苯丙氨酸置于对甲苯磺酸体系中,用 乙腈 用作溶剂,化学反应 0.05H,以88%的收率获得fmoc-(S)-2-四氢异喹啉乙酸
参考文献:容易合成fmoc-N-甲基化的α-和β-氨基酸
标题:容易合成fmoc-N-甲基化的α-和β-氨基酸
摘要:已经开发了通过中间体恶唑烷酮/恶二酮酮从相应的fmoc-氨基酸高效且环保的合成fmoc-N-甲基α-和β-氨基酸的方法.恶唑烷酮的合成需要微波加热3分钟,而路易斯酸催化的还原开孔仅需1分钟即可完成.因此,适用于例如固相肽合成的fmoc-N-甲基氨基酸可容易地在不到1小时内由相应的fmoc氨基酸制备,包括纯化.将fmoc-β 3-Homophenyl丙氨酸表明未预料到的反应性,并提供了一个单步路线高度有用的fmoc保护的1,2,3,4-Tetrahydroisoquinolineaceticacid,即β-Htic类似物.
Doi:10.1016/j.Tetlet.2006.01.085

专利信息

专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:US-2007042401-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries

专利号:US-2012245040-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries

专利号:US-2009062147-A1
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries

专利号:US-7972994-B2
优先权日:2003-12-17
标 题 :Methods for synthesis of encoded libraries

专利号:US-7935658-B2
优先权日:2003-12-17
标 题 :Methods for synthesis of encoded libraries