CAS: 268203-93-6; 3-(1-Methyl-7-Oxo-3-Propyl-6,7-Dihydro-1H-Pyrazolo[4,3-D]Pyrimidin-5-yl)-N-(2-(1-Methylpyrrolidin-2-yl)Ethyl)-4-Propoxybenzenesulfonamide

上下游产品

5-(5-Chlorosulphonyl-2-N-Propoxyphenyl)-1-Methyl-3-N-Propyl-1,6-Dihydro-7H-Pyrazolo[4,3-D]Pyrimidin-7-One 139756-24-4
1-Methyl-3-Propyl-5-(2-Propoxyphenyl)-1,6-Dihydro-7H-Pyrazolo[4,3-D]Pyrimidin-7-One 139756-23-3
西地那非 Viagra 139755-83-2
1-Methyl-5-(5-Morpholinoacetyl-2-N-Propoxyphenyl)-3-N-Propyl-1,6-Dihydro-7H-Pyrazolo[4,3-D]Pyrimidin-7-One 147676-63-9
1-甲基-4-[[5-[[[2-(1-甲基-2-吡咯烷基)乙基]氨基]磺酰基]-2-丙氧基苯甲酰基]氨基]-3-丙基-1H-吡唑-5-甲酰胺 2-Methyl-4-{5-[2-(1-Methyl-Pyrrolidin-2-yl)-Ethylsulfamoyl]-2-Propoxy-Benzoylamino}-5-Propyl-2H-Pyrazole-3-Carboxamide 382592-28-1
N-[3-(1,3-Dimethyl-4-Oxo-2H-Pyrazolo[3,4-D]Pyrimidin-6-yl)-4-Propoxyphenyl]Methanesulfonamide
3-[[[5-(氨基羰基)-1-甲基-3-丙基-1H-吡唑-4-基]氨基]羰基]-4-丙氧基-苯磺酰氯 4-(5-Chlorosulfonyl-2-N-Propoxybenzamido)-1-Methyl-3-N-Propylpyrazole-5-Carboxamide 374776-34-8

📜1-Methyl-3-Propyl-5-(2-Propoxyphenyl)-1,6-Dihydro-7H-Pyrazolo[4,3-D]Pyrimidin-7-One置于氯磺酸,氯化亚砜体系中,化学反应 1.0H,反应生成乌地那非
参考文献:一种杂环化合物的制备方法
标题:一种杂环化合物的制备方法
摘要:本发明属于化学医药技术领域,具体涉及以优地那非为代表的一类杂环化合物的制备方法.本发明要解决的技术问题是现有合成方法的生产成本高,收率低,废酸废气的处理量大,存在安全隐患.本发明解决上述技术问题的方案是提供一种杂环化合物的制备方法,包括以下步骤:1,起始原料a在有机溶剂和碱的作用下,反应生成中间体1;2,中间体1与磺化剂反应,生成中间体2;3,中间体2与起始原料b在有机溶剂中反应,得到终产物式i化合物.本发明提供的制备方法,所需原料易得,价格低廉,避免了昂贵的耦合试剂,提高了下步磺化反应的选择性,产品收率和纯度高,反应条件温和,利于车间生产放大.

专利信息

专利号:WO-2008084057-A1
优先权日:2007-01-10
标题:Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:SOLVAY PHARM BV; LANGE JOSEPHUS H M; KRUSE CORNELIS G
摘要:This invention relates to compounds with a combination of cannabinoid-CB1antagonism and serotonin reuptake inhibition to pharmaceutical compositions containing these compounds, to methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders. In particular the invention relates to compoundsof the general formula (I): wherein the symbols have the meanings given in the specification.

专利号:EP-4630405-A1
优先权日:2022-12-06
标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

专利号:US-8138174-B2
优先权日:2007-01-10
标 题:Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; SOLVAY PHARM BV
摘要:Compounds with a combination of cannabinoid CB 1 antagonism and serotonin reuptake inhibition, pharmaceutical compositions containing these compounds, methods for preparing these compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing these compositions are disclosed. Uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders are disclosed. n In at least one embodiment, the invention relates to compounds of the general formula (1): n nwherein the substitutents have the definitions given in the specification.

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2024123815-A1
优先权日:2022-12-06
标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

专利号:US-8796286-B2
优先权日:2005-06-10
标 题:Agent for treatment of liver diseases containing pyrazolopyrimidinone derivative
发明人：CHOI SEUL MIN; AHN BYONG OK; YOO MOOHI
权利人:CHOI SEUL MIN; AHN BYONG OK; YOO MOOHI; MEZZION PHARMA CO LTD
摘要:The present invention relates to the pharmaceutical composition for prevention and treatment of liver diseases containing pyrazolopyrimidine derivative as an active ingredient. According to the present invention, pyrazolopyrimidine derivative has an excellent effect on inhibiting collagen synthesis in hepatic stellate cells and acts directly on the portal vein. Particularly, it may increase the diameter and the amount of blood flow of the portal vein, and finally decrease the pressure thereof. Therefore, pyrazolopyrimidine derivative can be used advantageously for prevention and treatment of hepatic fibrosis, liver cirrhosis caused by hepatic fibrosis, portal hypertension and various complications caused by portal hypertension. In addition, pyrazolopyrimidine derivative according to the present invention can reduce dosing frequency because of its long half-life, and therefore, has an advantage to improve the drug compliance of patients suffering from chronical liver diseases.