CAS: 2449-05-0; Dibenzyl Diazene-1,2-Dicarboxylate

上下游产品

bis(phenylmethyl) 1,2-hydrazinedicarboxylate benzyl chloroformate5-benzyloxy-[1,3,4]oxadiazole-2,3-dicarboxylic acid 3-benzyl ester 2-ethyl ester Glyoxylsaeureethylester-(N-dibenzyloxycarbonyl-hydrazon) 17H14Br2N2O4C17H14Br2N2O4 17H14Cl2N2O4C17H14Cl2N2O4

聯胺置于吡啶,溴体系中,用 二氯甲烷 用作溶剂,化学反应 1.5H,以90%的收率获得偶氮二甲酸二苄酯
参考文献:黄素和可见光介导的mitsunobu反应条件下的光催化酯化†
标题:黄素和可见光介导的mitsunobu反应条件下的光催化酯化†
摘要:证明了基于黄素的空中光氧化在mitsunobu反应条件下进行酯化反应中的有用性,从而提供了从相应的二烷基肼二羧酸二乙酯中回收/生成空中二烷基偶氮二羧酸酯的方法.同时,通过黄素的光诱导电子转移激活三苯膦(ph 3 P)可以使无偶氮试剂进行酯化.已显示使用3-乙酸甲基黄酮黄素四乙酸酯(10%),氧气(末端氧化剂),可见光(450 Nm),Ph 3 P和二羧酸肼二甲酸二烷基酯(10%)的优化系统可提供各种醇的高效立体选择性偶联和酸变成酯,并保留构型.
Doi:10.1039/c6Ob02770A

专利信息

专利号:US-4287123-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R is a readily removable carboxyl protecting group; and is a readily removable acyl group.

专利号:US-4282148-A
优先权日:1980-01-14
标 题:Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

专利号:US-4414155-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

专利号:WO-2015193910-A1
优先权日:2014-06-20
标题:Asymmetric synthesis of 2-substituted indolines and 3-substituted cinnolines
发明人：KUMAR BOOPATHY SENTHIL; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a novel one step proline catalyzed process for synthesis of chiral hydrazine and its derivatives from o-bromo hydro cinamaldehyde. Further, it relates to a novel one step process for the synthesis of substitued indolines and cinnolines from chiral hydrazines and its derivatives.

专利号:US-8440844-B2
优先权日:2011-06-21
标题 :Process for the preparation of β-amino alcohol
发明人：RAWAT VARUN; CHOUTHAIWALE PANDURANG VILASRAO; CHAVAN VILAS BHIKU; SURYAVANSHI GURUNATH MALLAPPA; SUDALAI ARUMUGAM
权利人:RAWAT VARUN; CHOUTHAIWALE PANDURANG VILASRAO; CHAVAN VILAS BHIKU; SURYAVANSHI GURUNATH MALLAPPA; SUDALAI ARUMUGAM; COUNCIL SCIENT IND RES
摘要:A high-yielding enantioselective synthesis of the bioactive (S)—N-(5-chlorothiophene-2-sulfonyl)-β,β-diethylalaniol (7.b.2), a Notch-1-sparing γ-secretase inhibitor metabolite (with EC 50 =28 nM) effective in reduction of Aβ production in vivo, has been realized starting from readily available 3-pentanone. The key steps of the synthesis are proline-catalyzed α-aminooxylation and α-amination of aldehyde; the latter contributing an overall yield of 50-75% and 90-99% enantiomeric excess.

专利号:US-8268936-B2
优先权日:2005-01-04
标题:Synthesis of hybrid block copolymers and uses thereof
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.