CAS: 2402-97-3; 3-Bromopyridine 1-Oxide

相似化合物

694-59-7 650140-84-4 1851-22-5

上下游产品

3-Bromopyridine pyridin-3-ylamine water 2,5-dibromopyridine N-oxide 3-aminopyridine-N-oxide 3-bromopyridine-2-carbonitrile 2-Cyano-5-bromopyridine 3-bromo-1-(p-cyanophenoxy)pyridinium tetrafluoroborate

3-溴吡啶置于n-(苯甲酸基)丁二酰亚胺,Peroxodicarbonate体系中,用 二氯甲烷,水 用作溶剂,以34 %的收率获得3-溴吡啶-N-氧化物
参考文献:使用电化学生成的过氧化二碳酸酯合成芳香族氮氧化物
标题:使用电化学生成的过氧化二碳酸酯合成芳香族氮氧化物
摘要:电化学产生的绿色平台氧化剂,如过氧化二碳酸盐(podic),在可持续化学方面构成了一项改变游戏规则的技术,同时作为电化学析氢中的替代反反应.过氧化二碳酸盐避免了浓过氧化氢溶液的储存和运输.我们在此公开了一种用于喹啉,吡啶和复杂叔胺的n-氧化的有效方法.苯酰氧基琥珀酰亚胺 (Posi) 的使用是获得n-氧化物(28 个实例)且分离收率高达 98% 的决定性因素.
Doi:10.1021/acs.Orglett.3C04386

专利信息

专利号:US-2017355648-A1
优先权日:2016-04-26
标题 :Synthesis of meta-substituted [18f]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine n-oxides

专利号:US-10160695-B2
优先权日:2016-04-26
标 题 :Synthesis of meta-substituted [18F]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine N-oxides
发明人：BRUGAROLAS PEDRO
权利人:UNIV CHICAGO
摘要:Disclosed herein are methods for the fluorination aromatic N-heterocyclic N-oxides that comprise at least one leaving group. The N-oxides may be reduced to the fluorinated aromatic N-heterocyclic amine analogs. This novel fluorination approach may be successfully applied for synthesizing aromatic N-heterocyclic compounds labeled with 18 F.

专利号:WO-2010096722-A1
优先权日:2009-02-20
标 题 :3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors
发明人：FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
权利人:TAKEDA PHARMACEUTICAL; FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
摘要:Claimed are intermediates in the synthesis of N-Arylmethyl-3-Oxo-2,3-dihydro- [1,2,4]triazolo[4,3-a]pyridine-6-carboxamides as well as a process (A) to arrive at 3-Oxo-2, 3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid. The triazolo[4,3-a]pyridine-6-carboxamides of formula (I) are used as soluble epoxide hydrolase inhibitors (sEH) having therapeutic effect in pathologic conditions such as hypertension, stroke, inflammatory processes, diabetes and a variety of cardiovascular diseases.