CAS: 23739-88-0; Triacetyl-β-Cyclodextrin

该化合物是β-环十二烯的化学改良衍生物,其中羟基组为乙酰,以强化其物理化学特性.这种修改提高了有机溶剂的溶性,增加了脂质,使之适合需要氢恐惧客人分子封装的应用.乙酰组与本地环十二烯相比,还具有更大的稳定性,防止酶退化.其孔状结构保留了宿主-访客的复杂能力,有利于在药物的交付,芳香稳定化和分析化学中使用.该衍生物的定制疏水恐度扩大了与非极化合物的兼容性,同时保持了母分子分子的分子识别特性.这些特性使得该物质在需要控制释放或增强生物利用率的配方中具有多功能性.

结构式图片

相似化合物

6291-42-5 22352-19-8 13223-83-1

上下游产品

CAS号108-24-7 乙酸酐 | CAS号7585-39-9 β-环糊精 | CAS号75-36-5 乙酰氯 | CAS号18162-48-6 叔丁基二甲基氯硅烷

合成工艺路线路线简述

    📜乙酸酐,Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成三乙酰基-β-环糊精
    参考文献:Schardinger糊精的研究;α,β和γ糊精的制备及其溶解度特征.
    标题:Schardinger糊精的研究;α,β和γ糊精的制备及其溶解度特征.
    摘要:
    Doi:10.1021/ja01169A100

    海关参考信息

    专利信息


    专利号:US-7217823-B2
    优先权日:2000-12-06
    标题:4,4-Disubstituted piperidines, and methods of use thereof
    发明人:HOEMANN MICHAEL Z
    权利人:SEPRACOR INC
    摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1134/s2070205123701277
    摘要:Kuraeva YG, Tugareva DA, Onuchak LA, Kapralova TS. Thermodynamics of Sorption of Organic Compounds by Sorbents Based on Supramolecular Liquid Crystal HPFAB and β-Cyclodextrin Derivatives under Gas Chromatography Conditions. Prot Met Phys Chem Surf. 2023 Dec;59(6):1104–12. doi: 10.1134/s2070205123701277.
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