专利号:US-7217823-B2 优先权日:2000-12-06 标题:4,4-Disubstituted piperidines, and methods of use thereof 发明人:HOEMANN MICHAEL Z 权利人:SEPRACOR INC 摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.
参考文献:10.1134/s2070205123701277 摘要:Kuraeva YG, Tugareva DA, Onuchak LA, Kapralova TS. Thermodynamics of Sorption of Organic Compounds by Sorbents Based on Supramolecular Liquid Crystal HPFAB and β-Cyclodextrin Derivatives under Gas Chromatography Conditions. Prot Met Phys Chem Surf. 2023 Dec;59(6):1104–12. doi: 10.1134/s2070205123701277.