专利号:US-9868767-B2 优先权日:2013-05-23 标 题:Chemical synthesis and screening of bicyclic peptide libraries 发明人:PEI DEHUA; UPADHYAYA PUNIT; LIAN WENLONG; TRINH THI 权利人:OHIO STATE INNOVATION FOUNDATION 摘要:Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:US-10092579-B2 优先权日:2016-01-07 标题:Gold(I) complexes with anticancer properties and methods of use thereof 发明人:ALTAF MUHAMMAD; MONIM-UL-MEHBOOB MUHAMMAD; ISAB ANVARHUSEIN ABDULKADIR; ALTUWAIJRI SALEH 权利人:UNIV KING FAHD PET & MINERALS 摘要:Monomeric and dimeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one phosphine-based ligand that may be monodentate or bidentate and at least one dithiocarbamate-based ligand that is monodentate. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.
专利号:US-9573967-B2 优先权日:2015-05-06 标 题 :N-heterocyclic carbene gold complexes with anticancer properties and methods of use thereof 发明人:ALTAF MUHAMMAD; ISAB ANVARHUSEIN ABDULKADIR 权利人:UNIV KING FAHD PET & MINERALS 摘要:Monomeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one N-heterocyclic carbene ligand and one monodentate dithiocarbamate-based ligand. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.
专利号:US-6797819-B1 优先权日:1998-06-11 标 题 :Alkaloids 发明人:SHAIR MATTHEW; WESTWOOD NICHOLAS; PELISH HENRY EFREM; KIRCHHAUSEN THOMAS; FENG YAN 权利人:HARVARD COLLEGE; CBR INST FOR BIOMED RES INC 摘要:The present invention provides novel alkaloid compounds and collections of these compounds, and provides methods for the synthesis of these compounds using biomimetic synthetic strategies. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as bacterial infections, proliferative diseases, and reproductive disorders, to name a few.
专利号:EP-2999483-A2 优先权日:2013-05-23 标 题:Chemical synthesis and screening of bicyclic peptide libraries
专利号:US-10501496-B2 优先权日:2013-05-23 标 题 :Chemical synthesis and screening of bicyclic peptide libraries