CAS: 18869-47-1; Methyl Tyrosinate

该化合物是一种有机化合物,其特点是氨基酸结构,特别是苯丙烯的衍生物;其特征是甲基酯功能组,氨基基基亚和附属于苯环的氢氧基,有助于其潜在的生物活动;该化合物一般是白色的,是白色的,是非白色的固体;由于存在羟基和氨基组,在水和酒精等极溶剂中可溶解;其分子结构允许氢结合,这可能影响其在生物系统中的再活性和相互作用;甲基2-氨基-3-(4-羟基苯基)丙胺丙酸酯可能对制药研究感兴趣,特别是开发具有潜在治疗作用的化合物,例如...

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68697-61-0 1080-06-4 3417-91-2

上下游产品

methanol L-tyrosine 3-(4-Hydroxy-phenyl)-2-((E)-3-oxo-propenylamino)-propionic acid methyl ester 3-(4-Hydroxy-phenyl)-2-((E)-2-methyl-3-oxo-propenylamino)-propionic acid methyl esterN-stearoyl-DL-tyrosine methyl esterN-stearoyl-DL-tyrosine methyl ester 2-diazo-3-(4-hydroxyphenyl)propanoic acid methyl ester methyl trityltyrosinate 3-(4-Hydroxy-phenyl)-2-[2-(1H-indol-3-yl)-2-oxo-acetylamino]-propionic acid methyl ester

合成工艺路线路线简述

    📜Dl-酪氨酸 反应生成2-氨基-3-(4-羟基苯基)丙酸甲酯
    参考文献:Buyuktimkin,Nadir;Buschauer,Armin,J. Chromatogr.,450,(1988) N 2,C. 281-283
    标题:Buyuktimkin,Nadir;Buschauer,Armin,J. Chromatogr.,450,(1988) N 2,C. 281-283

    海关参考信息

    专利信息


    专利号:US-6825378-B2
    优先权日:2003-03-28
    标 题 :Process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid
    发明人:KUMAR PRADEEP; FERNANDES RODNEY AGUSTINHO; GUPTA PRITI
    权利人:COUNCIL SCIENT IND RES
    摘要:The present invention provides a process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1). The present invention more particularly relates to a process using cyclohexylphenyl ketone for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1).

    专利号:US-6140529-A
    优先权日:1998-10-22
    标 题 :Synthesis of optically active cyclohexylphenylglycolate esters
    发明人:BAKALE ROGER P; LOPEZ JORGE L; MCCONVILLE FRANCIS X; VANDENBOSSCHE CHARLES P; SENANAYAKE CHRIS HUGH
    权利人:SEPRACOR INC
    摘要:A process for the preparation of optically active cyclohexylphenylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargyl alcohol derivatives. The preparation of the hydrochloride salt is also described. In addition, a resolution process employing tyrosine methyl ester enantiomers for preparing a single enantiomer of CHPGA from racemic CHPGA is disclosed.

    专利号:WO-9812201-A1
    优先权日:1996-09-23
    标题 :Phosphorylating reagents
    发明人:GANI DAVID; HILLIER MARK; HORMOZDIARI PANTEA
    权利人:UNIV ST ANDREWS; GANI DAVID; HILLIER MARK; HORMOZDIARI PANTEA
    摘要:There is provided a phosphorylating reagent for phosphrylation of amino acids or compounds formed therefrom. The phosphorylating reagent is of utility in solution or solid-phase chemistry, and particularly for the solid-phase synthesis of phosphorylated peptides and combinational libraries of phosphorylated organic compounds. Also provided for is a method of phosphorylating oxygen, nitrogen and sulphur nucleophides, for example amino acid and peptides.

    专利号:US-2024018109-A1
    优先权日:2020-06-19
    标题 :Method for synthesis of roxadustat and intermediate thereof, and intermediate thereof

    专利号:US-11040939-B1
    优先权日:2020-06-23
    标 题 :N-transfer reagent and method for preparing the same and its application
    发明人:CHOU HO-HSUAN; LU GUAN-HAN; HSUEH HSIAO-CHIN; HUANG TZU-CHIA
    权利人:UNIV NAT CHENG KUNG
    摘要:Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): n n n n n n n n n n The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

    专利号:US-4339390-A
    优先权日:1979-09-18
    标题:Preferential immunoreactivity of syn-isomer of cortisol derivative
    发明人:ALI AKHTAR; TSUI PAULUS T K
    权利人:ABBOTT LAB
    摘要:The synthesis, resolution, radiolabeling and determination of the superior immunoreactivity of the syn isomer of a derivative of cortisol-21-acetate is described.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/s00726-011-0931-1
    摘要:Abdolmaleki A, Mallakpour S, Borandeh S, Sabzalian MR. Fabrication of biodegradable poly(ester-amide)s based on tyrosine natural amino acid. Amino Acids. 2012 May;42(5):1997–2007. doi: 10.1007/s00726-011-0931-1.
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