专利号:US-6825378-B2 优先权日:2003-03-28 标 题 :Process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid 发明人:KUMAR PRADEEP; FERNANDES RODNEY AGUSTINHO; GUPTA PRITI 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1). The present invention more particularly relates to a process using cyclohexylphenyl ketone for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1).
专利号:US-6140529-A 优先权日:1998-10-22 标 题 :Synthesis of optically active cyclohexylphenylglycolate esters 发明人:BAKALE ROGER P; LOPEZ JORGE L; MCCONVILLE FRANCIS X; VANDENBOSSCHE CHARLES P; SENANAYAKE CHRIS HUGH 权利人:SEPRACOR INC 摘要:A process for the preparation of optically active cyclohexylphenylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargyl alcohol derivatives. The preparation of the hydrochloride salt is also described. In addition, a resolution process employing tyrosine methyl ester enantiomers for preparing a single enantiomer of CHPGA from racemic CHPGA is disclosed.
专利号:WO-9812201-A1 优先权日:1996-09-23 标题 :Phosphorylating reagents 发明人:GANI DAVID; HILLIER MARK; HORMOZDIARI PANTEA 权利人:UNIV ST ANDREWS; GANI DAVID; HILLIER MARK; HORMOZDIARI PANTEA 摘要:There is provided a phosphorylating reagent for phosphrylation of amino acids or compounds formed therefrom. The phosphorylating reagent is of utility in solution or solid-phase chemistry, and particularly for the solid-phase synthesis of phosphorylated peptides and combinational libraries of phosphorylated organic compounds. Also provided for is a method of phosphorylating oxygen, nitrogen and sulphur nucleophides, for example amino acid and peptides.
专利号:US-2024018109-A1 优先权日:2020-06-19 标题 :Method for synthesis of roxadustat and intermediate thereof, and intermediate thereof
专利号:US-11040939-B1 优先权日:2020-06-23 标 题 :N-transfer reagent and method for preparing the same and its application 发明人:CHOU HO-HSUAN; LU GUAN-HAN; HSUEH HSIAO-CHIN; HUANG TZU-CHIA 权利人:UNIV NAT CHENG KUNG 摘要:Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): n n n n n n n n n n The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.
专利号:US-4339390-A 优先权日:1979-09-18 标题:Preferential immunoreactivity of syn-isomer of cortisol derivative 发明人:ALI AKHTAR; TSUI PAULUS T K 权利人:ABBOTT LAB 摘要:The synthesis, resolution, radiolabeling and determination of the superior immunoreactivity of the syn isomer of a derivative of cortisol-21-acetate is described.
参考文献:10.1007/s00726-011-0931-1 摘要:Abdolmaleki A, Mallakpour S, Borandeh S, Sabzalian MR. Fabrication of biodegradable poly(ester-amide)s based on tyrosine natural amino acid. Amino Acids. 2012 May;42(5):1997–2007. doi: 10.1007/s00726-011-0931-1.