CAS: 179899-07-1; 4-Fluoro-2-Methoxyphenylboronic Acid

(4-Fluoro-2-Methoxyphenyl)-Dimethoxyborane置于盐酸体系中,化学反应生成4-氟-2-甲氧基苯硼酸
参考文献:Substituted 3-Amino Biaryl Propionic Acids As Potent Vla-4 Antagonists
标题:Substituted 3-Amino Biaryl Propionic Acids As Potent Vla-4 Antagonists
摘要:A Series Of Substituted N-(3,5-Dichlorobenzenesulfonyl)-(L)-Prolyl-And (L)-Azetidyl-Beta-Biaryl Beta-Alanine Derivatives Was Prepared As Selective And Potent Vla-4 Antagonists. The 2,6-Dioxygenated Biaryl Substitution Pattern Is Important For Optimizing Potency. Oral Bioavailability Was Variable And May Be A Result Of Binding To Circulating Plasma Proteins. (C) 2002 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0960-894X(02)00460-2

专利信息

专利号:US-9951062-B2
优先权日:2012-12-14
标 题 :Substituted 1 H-pyrrolo [2, 3-b] pyridine and 1 H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANIPISETTY VENU BABU; TALLURI SURESHKUMAR; APPALANENI RAJENDRA P
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:Compounds according to Formulas I, IA or IB: n nto pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and/or disorders such as cancer, stroke, cardiovascular, obesity and type II diabetes.

专利号:WO-2024179572-A1
优先权日:2023-03-01
标题:Aromatic-ring compound and use thereof
发明人：LI JIN; WANG QINGYANG; WANG XIAOTAO; LI XIAOMEI; DOU DENGFENG; MENG XIAOYUN; LI XIANYANG; CHEN QIUXIA; GUO ANPING; Zheng nuo; HU HONG; HE WEI
权利人:HITGEN INC
摘要:Provided are a new compound having a binding effect on the E3 ligase protein TRIM21, and the use thereof in the preparation of a drug for treating abnormal cell proliferation diseases. Further provided is an intermediate compound in the synthesis process of a proteolysis-targeting bifunctional compound.

专利号:EP-2118111-B1
优先权日:2007-02-06
标题 :2-amin0-5, 7-dihydr0-6h- pyrrolo [3, 4-d] pyrimidine derivatives as hsp-90 inhibitors for treating cancer
发明人：BENNETT MICHAEL JOHN; ZEHNDER LUKE RAYMOND; NINKOVIC SACHA; KUNG PEI-PEI; MENG JERRY JIALUN; HUANG BUWEN
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors.