CAS: 1707289-21-1; N-((3S,4S)-3-((6-(2,6-Dichloro-3,5-Dimethoxyphenyl)Quinazolin-2-yl)Amino)Tetrahydro-2H-Pyran-4-yl)Acrylamide
- 英文名称N-((3S,4S)-3-((6-(2,6-Dichloro-3,5-Dimethoxyphenyl)Quinazolin-2-yl)Amino)Tetrahydro-2H-Pyran-4-yl)Acrylamide
- 中文名称N-((3S,4S)-3-((6-(2,6-二氯-3,5-二甲氧基苯基)喹唑啉-2-基)氨基)四氢-2H-吡喃-4-基)丙烯酰胺
- IUPAC名称N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide
- 其它别名4-Hydroxy-8-Methoxyquinoline-3-Carboxylic Acid Ethyl Ester, Aldrichcpr; Inchi=1/c13H10O3/c14-12-7-5-10(6-8-12)9-1-3-11(4-2-9)13(15)16/h1-8,14H,(H,15,16; N-[(3S,4S)-3-
- CAS编号1707289-21-1
- MFCD编号:MFCD30496704
- FDA UNII编号:5Q7R99CKV2
- 分子式:C24H24Cl2N4O4分子量:503.39
- 产品CID: 870462
- 产品分类生物化工 → 生化试剂 → 激动剂抑制剂
物理性质
合成工艺路线路线简述
📜2-氯-6-(2,6-二氯-3,5-二甲氧基苯基)喹唑啉置于盐酸,Palladium On Activated Charcoal,氢气,Sodium Carbonate,N,N-二异丙基乙胺体系中,用 N-甲基吡咯烷酮,甲醇,二氯甲烷,水,乙酸乙酯 用作溶剂,化学反应 1.5H,反应生成N-((3S,4S)-3-((6-(2,6-二氯-3,5-二甲氧基苯基)喹唑啉-2-基)氨基)四氢-2H-吡喃-4-基)丙烯酰胺
参考文献:Inhibitors Of The Fibroblast Growth Factor Receptor
标题:Inhibitors Of The Fibroblast Growth Factor Receptor
摘要:本处描述的是fgfr-4的抑制剂,包括含有此类化合物的药物组合物,以及使用此类化合物和组合物的方法.
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2903919090-氯苯
2905121000-正丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Kim RD, Sarker D, Meyer T, Yau T, Macarulla T, Park JW, Choo SP, Hollebecque A, Sung MW, Lim HY, Mazzaferro V, Trojan J, Zhu AX, Yoon JH, Sharma S, Lin ZZ, Chan SL, Faivre S, Feun LG, Yen CJ, Dufour JF, Palmer DH, Llovet JM, Manoogian M, Tugnait M, Stransky N, Hagel M, Kohl NE, Lengauer C, Sherwin CA, Schmidt- Kittler O, Hoeflich KP, Shi H, Wolf BB, Kang YK. First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma. Cancer Discov. 2019 Dec;9(12):1696-1707. doi: 10.1158/2159-8290.CD-19-0555. Epub 2019 Oct 1.
151:104567. doi: 10.1016/j.phrs.2019.104567. Epub 2019 Nov 23.
573:118842. doi: 10.1016/j.ijpharm.2019.118842. Epub 2019 Nov 20. 15(7):860. doi: 10.3390/ph15070860.
合成参考文献
参考文献:10.1007/16833_2022_96
摘要:Zhang H, Zhao J, Yang W, Li Z, Gong L, Li Y. Liver Cancer: Interdisciplinary Approach. 2022. In: Interdisciplinary Cancer Research.
参考文献:10.1007/978-981-96-7336-0_1
摘要:Kumar R, Yadav M, Tanwar P, Pal S, Sabarwal A. Structural Features and Signaling Mechanisms of Receptor Tyrosine Kinases in Cancer. 2025. In: Molecular Targets in Cancer Therapy.
参考文献:10.1038/s44355-025-00038-8
摘要:Nevi L, Aiello C, Molinaro F, Altomare A, Musarra T, Gallo P, Taffon C, Guarino MP, Vespasiani-Gentilucci U, Baiocchini A, Carotti S. Decoding the molecular and genomic landscape of hepatocellular carcinoma: biomarker discovery, classification frameworks, and therapeutic targeting. npj Gut Liver. 2025 Oct 01;2(1). doi: 10.1038/s44355-025-00038-8.
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