CAS: 169032-17-1; 2-[4-(4-Chloro-Butyryl)-Phenyl]-2-Methyl-Propionitrile

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2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide 2-(4-bromophenyl)-2-methylpropanenitrile 4-Chlorobutanoyl chloride 2-methyl-2-phenylpropionic acid 2-[4-(4-Chloro-butyryl)-phenyl]-2-methyl-propionic acid, methyl ester 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionic acid 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile

📜Alpha,Alpha-二甲基苯乙酸置于甲醇,Ammonium Hydroxide,Sodium Hydroxide,Lithium Aluminium Tetrahydride,三氯化铝,Jones Reagent,草酰氯,Sodium Carbonate,4-吡咯烷基吡啶,对甲苯磺酸,三乙胺,三氯氧磷体系中,用 四氢呋喃,二硫化碳,乙醚,丙酮,乙腈,苯 用作溶剂,化学反应 31.83H,反应生成非索非那定杂质8
参考文献:羧基terfenadine(非索非那定)及其生物等位四唑类似物的新合成.
标题:羧基terfenadine(非索非那定)及其生物等位四唑类似物的新合成.
摘要:描述了基于α-卤代-烷基芳基酮到相应的取代的2-芳基链烷酸酯的转化的羧基特非那定(4)的新合成.据报道其两个生物等位四唑类似物的对映选择性合成以及初步的生物学结果.
Doi:10.1016/s0014-827X(99)00070-1