专利号:US-9522932-B2 优先权日:2004-03-04 标 题 :Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production 发明人:HERDEWIJN PIET; PANNECOUQUE CHRISTOPHE; WU TONGFEI; DE CLERCQ ERIK 权利人:LEUVEN K U RES & DEV 摘要:The invention is directed to a process for the preparation of substituted threonolactone and substituted threose compounds which are intermediates in the synthesis of phosphonate nucleosides being useful antiviral agents.
专利号:US-10335382-B2 优先权日:2013-06-14 标 题:Use of hydrogen sulfide synthesis inhibitors for cancer therapy 发明人:HELLMICH MARK; ZHOU JIA; SZABO CSABA 权利人:HELLMICH MARK; ZHOU JIA; SZABO CSABA; UNIV TEXAS 摘要:In certain aspects the methods comprise administering an inhibitor of hydrogen sulfide biosynthesis, a cystathionine-β-synthase (CBS) inhibitor, or a hydrogen sulfide neutralizing agent to a patient having a cancer associated with elevated production of hydrogen sulfide.
专利号:US-7572579-B2 优先权日:2004-02-27 标 题:Screening method for a ribonuclease H inhibitor of a reverse transcriptase 发明人:YOSHINAGA TOMOKAZ; SHISHIDO TAKAO 权利人:SHIONOGI & CO 摘要:A screening method for a compound which inhibits a ribonuclease H activity of a reverse transcriptase which includes incubating a substrate with an appropriate primer hybridized to an appropriate template, a metal ion and a reverse transcriptase to form a complex, adding a test substance, and after these steps adding dNTPs to initiate DNA synthesis, measuring the amount of nucleic acid cleaved from the template, and comparing the measured value with a measured value in the absence of a test substance.
专利号:US-5670130-A 优先权日:1989-08-09 标 题 :Zeolite L preparation 发明人:VERDUIJN JOHANNES P 权利人:EXXON CHEMICAL PATENTS INC ECP 摘要:Zeolite L containing caesium having enhanced catalytic properties is prepared by a process in which said zeolite L is crystallized from a synthesis mixture with a molar composition (expressed as oxides) of: - K2O/SiO2 0.22 to 0.30 - K2O/Cs2O 5 to 12 - H2O/K2O 50 to 90 - and - SiO2/Al2O3 6.0 to 7.0 - and containing 0.5 to 20 ppm (by weight) of divalent metal cations, e.g. Mg ions. The zeolite L can form part of a dehydrocyclization and/or isomerisation catalyst.
专利号:US-2019336462-A1 优先权日:2013-06-14 标题 :Use of hydrogen sulfide synthesis inhibitors for cancer therapy
专利号:US-2016095831-A1 优先权日:2013-06-14 标 题:Use of hydrogen sulfide synthesis inhibitors for cancer therapy
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