CAS: 129-46-4; Sodium 8,8'-((3,3'-((3,3'-(Carbonylbis(Azanediyl))Bis(Benzoyl))Bis(Azanediyl))Bis(4-Methylbenzoyl))Bis(Azanediyl))Bis(Naphthalene-1,3,5-Trisulfonate)

该化合物是一种多硫凝固的环烷基素化合物,广泛应用于生物化学和药理研究,是各种酶的竞争性抑制剂,包括逆转转转录酶和蛋白类酶,对研究信号传输途径很有价值;该化合物具有抗寄生虫和抗病毒特性,特别是针对锥虫和氟化病毒;其生理条件下的高水溶性和稳定性增强了其在体外和活性研究中的效用;苏拉明钠盐还用于调查对P2受体的对立效应造成的纯基信号;该产品作为高纯度的钠盐供应,确保实验应用的一贯性.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号10397-30-5 4-甲基-3-硝基苯甲酰氯

合成工艺路线路线简述

  • 合成目标产物 Suramin Sodium 主要起始原料 4-Methyl-3-Nitrobenzoyl Chloride
  • (文献来源)合成步骤主要原料 4-Methyl-3-Nitrobenzoyl Chloride

专利信息


专利号:US-9522932-B2
优先权日:2004-03-04
标 题 :Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production
发明人:HERDEWIJN PIET; PANNECOUQUE CHRISTOPHE; WU TONGFEI; DE CLERCQ ERIK
权利人:LEUVEN K U RES & DEV
摘要:The invention is directed to a process for the preparation of substituted threonolactone and substituted threose compounds which are intermediates in the synthesis of phosphonate nucleosides being useful antiviral agents.

专利号:US-10335382-B2
优先权日:2013-06-14
标 题:Use of hydrogen sulfide synthesis inhibitors for cancer therapy
发明人:HELLMICH MARK; ZHOU JIA; SZABO CSABA
权利人:HELLMICH MARK; ZHOU JIA; SZABO CSABA; UNIV TEXAS
摘要:In certain aspects the methods comprise administering an inhibitor of hydrogen sulfide biosynthesis, a cystathionine-β-synthase (CBS) inhibitor, or a hydrogen sulfide neutralizing agent to a patient having a cancer associated with elevated production of hydrogen sulfide.

专利号:US-7572579-B2
优先权日:2004-02-27
标 题:Screening method for a ribonuclease H inhibitor of a reverse transcriptase
发明人:YOSHINAGA TOMOKAZ; SHISHIDO TAKAO
权利人:SHIONOGI & CO
摘要:A screening method for a compound which inhibits a ribonuclease H activity of a reverse transcriptase which includes incubating a substrate with an appropriate primer hybridized to an appropriate template, a metal ion and a reverse transcriptase to form a complex, adding a test substance, and after these steps adding dNTPs to initiate DNA synthesis, measuring the amount of nucleic acid cleaved from the template, and comparing the measured value with a measured value in the absence of a test substance.

专利号:US-5670130-A
优先权日:1989-08-09
标 题 :Zeolite L preparation
发明人:VERDUIJN JOHANNES P
权利人:EXXON CHEMICAL PATENTS INC ECP
摘要:Zeolite L containing caesium having enhanced catalytic properties is prepared by a process in which said zeolite L is crystallized from a synthesis mixture with a molar composition (expressed as oxides) of: - K2O/SiO2 0.22 to 0.30 - K2O/Cs2O 5 to 12 - H2O/K2O 50 to 90 - and - SiO2/Al2O3 6.0 to 7.0 - and containing 0.5 to 20 ppm (by weight) of divalent metal cations, e.g. Mg ions. The zeolite L can form part of a dehydrocyclization and/or isomerisation catalyst.

专利号:US-2019336462-A1
优先权日:2013-06-14
标题 :Use of hydrogen sulfide synthesis inhibitors for cancer therapy

专利号:US-2016095831-A1
优先权日:2013-06-14
标 题:Use of hydrogen sulfide synthesis inhibitors for cancer therapy

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Liu N, Zhuang S. Tissue protective and anti-fibrotic actions of suramin: new uses of an old drug. Curr Clin Pharmacol. 2011 May;6(2):137-42. Review. Review. Review. Epub 2003 Jan 31. Review. Review. Review. Review. Review. Review. Review. Review. Spanish. Review. Review. Review. Review. Review. Review. Review. Review. Review.

合成参考文献


参考文献:10.4061/2011/518258
摘要:Calderano SG, de Melo Godoy PD, da Cunha JP, Elias MC. Trypanosome prereplication machinery: a potential new target for an old problem. Enzyme Res. 2011;2011():518258.
参考文献:10.1074/jbc.m510452200
摘要:Nandigama R, Padmasekar M, Wartenberg M, Sauer H. Feed Forward Cycle of Hypotonic Stress-induced ATP Release, Purinergic Receptor Activation, and Growth Stimulation of Prostate Cancer Cells. Journal of Biological Chemistry. 2006 Mar;281(9):5686–93. doi: 10.1074/jbc.m510452200.
参考文献:10.1155/2011/189876
摘要:Niu YG, Evans RD. Very-low-density lipoprotein: complex particles in cardiac energy metabolism. J Lipids. 2011;2011():189876.
参考文献:10.1182/blood-2005-06-2314
摘要:Khine AA, Del Sorbo L, Vaschetto R, Voglis S, Tullis E, Slutsky AS, Downey GP, Zhang H. Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway. Blood. 2006 Apr 01;107(7):2936–42. doi: 10.1182/blood-2005-06-2314.
参考文献:10.1016/j.tox.2011.07.001
摘要:Hara S, Mizukami H, Kuriiwa F, Mukai T. cAMP production mediated through P2Y(11)-like receptors in rat striatum due to severe, but not moderate, carbon monoxide poisoning. Toxicology. 2011 Oct 09;288(1-3):49–55. doi: 10.1016/j.tox.2011.07.001.
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