CAS: 1193-55-1; 2-Methylcyclohexane-1,3-Dione

相似化合物

562-13-0 4056-73-9 14203-46-4

上下游产品

CAS号504-02-9 1,3-环己二酮 | CAS号608-25-3 2,6-二羟基甲苯 | CAS号74-88-4 碘甲烷 | CAS号5073-65-4 2-methyl-2-(3-o... | CAS号25435-93-2 1,5-dimethoxy-3... | CAS号50650-22-1 thallium(I) 2,6... | CAS号125493-39-2 ((5-(4,4-dimeth... | CAS号608-25-3 2,6-二羟基甲苯 | CAS号102547-88-6 trans-3-hydroxy... | CAS号143008-67-7 2,4-dimethyl-3-... | CAS号14782-52-6 6,6-二甲基-1,4-二噁螺... | CAS号147068-28-8 2-methyl-3-phen... | CAS号90-96-0 4,4'-二甲氧基二苯甲酮 | CAS号142605-78-5 4,4-bis(4-metho... | CAS号591-49-1 1-甲基-1-环己烯 | CAS号90-98-2 4,4'-二氯二苯甲酮

1,3-环己二酮置于palladium-Carbon 盐酸,聚合甲醛,二甲胺体系中,用 甲醇,水 用作溶剂,以87%的收率获得2-甲基-1,3-环己二酮
参考文献:Process For Producing 2-Methyl-1,3-Cyclohexanedione And
标题:Process For Producing 2-Methyl-1,3-Cyclohexanedione And
摘要:一种生产2-甲基-1,3-环己二酮的方法,包括将1,3-环己二酮,甲醛和二烷基胺进行曼尼希反应以获得2-二烷基氨甲基-1,3-环己二酮,然后将2-二烷基氨甲基进行氢解反应;以及一种生产2-甲基邻苯二酚的方法,包括对获得的2-甲基-1,3-环己二酮进行芳构化.根据这些方法,可以轻松且具有优势地商业化生产高纯度的2-甲基邻苯二酚和2-甲基-1,3-环己二酮.

专利信息

专利号:US-4110380-A
优先权日:1974-05-06
标题 :Asymmetric synthesis of organic compounds
发明人：HAJOS ZOLTAN GEORGE; PARRISH DAVID RICHARD
权利人:HOFFMANN LA ROCHE
摘要:Optically active organic compounds are prepared starting from optically inactive reactants by means of an optically active agent which influences the course of the reaction. In particular optically active compounds having a 'meso' type carbon atom undergo an intramolecular ring closure in the presence of an optically active agent to yield an optically active product having one additional ring. The present process is particularly useful in the preparation of optically active bicyclic diketones which are important intermediates in the total synthesis of steroids.

专利号:US-4080334-A
优先权日:1968-11-22
标题:Intermediates in the total synthesis employing substituted isoxazole derivatives
发明人：SAUCY GABRIEL; SCOTT JOHN WILLIAM
权利人:HOFFMANN LA ROCHE
摘要:The intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-norsteroids. Further, the intermediates and processes of the invention provide a route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 19β-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereo-specific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

专利号:US-3985771-A
优先权日:1968-11-22
标题:Total steroid synthesis employing substituted isoxazole derivatives
发明人：SAUCY GABRIEL; SCOTT JOHN WILLIAM
权利人:HOFFMANN LA ROCHE
摘要:The novel intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-nor-steroids. Further, the intermediates and processes of the invention provide a novel route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 13β-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereo-specific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

专利号:US-12098115-B2
优先权日:2016-09-15
标 题:Methods and compositions for terpenoid synthesis
发明人：GRENNING ALEXANDER JAMES
权利人:UNIV FLORIDA
摘要:In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-4044004-A
优先权日:1968-11-22
标题 :Total steroid synthesis employing substituted isoxazole derivatives
发明人：SAUCY GABRIEL; SCOTT JOHN WILLIAM
权利人:HOFFMANN LA ROCHE
摘要:The novel intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-norsteroids. Further, the intermediates and processes of the invention provide a novel route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 19β-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereospecific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

专利号:US-8067465-B2
优先权日:2002-01-15
标题:Tricyclic-bis-enone derivatives and methods of use thereof
发明人：HONDA TADASHI; FAVALORO FRANK G; GRIBBLE GORDON W; SPORN MICHAEL B; SUH NANJOO
权利人:HONDA TADASHI; FAVALORO FRANK G; GRIBBLE GORDON W; SPORN MICHAEL B; SUH NANJOO; DARTMOUTH COLLEGE
摘要:Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotropic lateral sclerosis, rheumatoid arthritis, inflammatory bowel disease, and all other diseases whose pathogenesis is believed to involve excessive production of either nitric oxide (NO) or prostaglandins or the overexpression of iNOS or COX-2 genes or gene products. Further, methods for the synthesis of the TBE compounds of the invention utilize cheap commercially available reagents and are highly cost effective and amenable to scale-up. Additional high efficiency synthetic methods that utilize novel intermediates as well as the synthesis of these intermediates are also provided. Furthermore, the invention also provides methods for designing novel and water-soluble TBEs.