CAS: 1146-39-0; 1-Nitro-4-(Phenylsulfonyl)Benzene

该化合物是一种硝基替代芳香磺化合物,其应用在有机合成和制药中间体中,其结构为硝基化合物和苯硫磺酰胺在苯环上的混合物,有助于其作为电极或交叉相交反应中积块的效用; 硫基和硝基苯组的电子抽取特性增强了核生殖替代和其他变异的再活性; 该化合物因其稳定性,定义明确的再活性和与各种合成条件的兼容性而备受重视; 它作为前体,用于准备更复杂的磺酰胺衍生物和其他功能化芳香系统,使其在医药和材料化学研究中成为有用的试剂.

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7019-01-4 31515-43-2 4779-36-6

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上下游产品

4-nitrophenyl phenyl sulfide 4-(4-nitrophenylsulfonyl)aniline sodium benzenesulfonate 4-chlorobenzonitrile 4-methoxyphenyl phenyl sulfone p-aminophenyl phenyl sulfone 3,4'-dinitrophenyl sulfone N-oxidebis-(4-benzenesulfonyl-phenyl)-diazene-N-oxide

合成工艺路线路线简述

    📜1-(Benzenesulfinyl)-4-Nitrobenzene置于双氧水体系中,用 溶剂黄146 用作溶剂,化学反应 5.0H,以97%的收率获得4-硝基联苯砜
    参考文献:Reactions Of Organic Anions. 161. Dihalomethylation Of Nitroarenes Via Vicarious Nucleophilic Substitution Of Hydrogen With Trihalomethyl Carbanions
    标题:Reactions Of Organic Anions. 161. Dihalomethylation Of Nitroarenes Via Vicarious Nucleophilic Substitution Of Hydrogen With Trihalomethyl Carbanions
    摘要:
    Doi:10.1021/jo00282A025

    海关参考信息

    专利信息


    专利号:US-7531694-B2
    优先权日:2004-07-07
    标题:Process for synthesis of 4-4′-diamino-diphenyl-sulfone
    发明人：VILLA MARCO; DE FAVERI CARLA; ZANOTTI RICCARDO; CIARDELLA FRANCESCO; BORIN FABRIZIO
    权利人:LUNDBECK PHARMACEUTICALS ITALY
    摘要:A new process for the preparation and purification of 4-4′-diamino-diphenyl-sulfone (dapsone) is described. The process described is a three step process comprising a condensation reaction with the synthesis of a thioether intermediate and then steps of oxidation and reduction in suitable conditions in order to obtain a product with good yield and purity.

    专利号:US-9650330-B2
    优先权日:2013-12-12
    标题 :Process for the synthesis of aryl sulfones
    发明人：MHASKE SANTOSH BABURAO; PANDYA VIRAT
    权利人:COUNCIL SCIENT IND RES
    摘要:The present patent discloses a novel, efficient and transition-metal-free room temperature single step process for synthesis of aryl sulfones and substituted aryl sulfones starting from aryl substrates.

    专利号:US-2008293970-A1
    优先权日:2004-07-07
    标 题:Process for Synthesis of 4-4'-Diamino-Diphenyl-Sulfone

    专利号:WO-2006002690-A1
    优先权日:2004-07-07
    标 题 :Process for synthesis of 4-4'-diamino-diphenyl-sulfone

    专利号:US-2016304447-A1
    优先权日:2013-12-12
    标 题 :A process for the synthesis of aryl sulfones

    专利号:EP-1778630-B1
    优先权日:2004-07-07
    标题 :Process for synthesis of 4-4'-diamino-diphenyl-sulfone

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    合成参考文献


    摘要:Ono, N., Science of Synthesis, (2006) 8, 770.
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