专利号:US-9845289-B2 优先权日:2014-08-01 标题 :Process for the synthesis of Dapsone and its intermediates 发明人:BARATELLA MARCO; CASTALDI GRAZIANO; CASTALDI MARTA; GABOARDI MAURO; PALLANZA GIUSEPPE 权利人:SEEGPHARM SA 摘要:A process for the synthesis of Dapsone and intermediates thereof are described.
专利号:US-7531694-B2 优先权日:2004-07-07 标题:Process for synthesis of 4-4′-diamino-diphenyl-sulfone 发明人:VILLA MARCO; DE FAVERI CARLA; ZANOTTI RICCARDO; CIARDELLA FRANCESCO; BORIN FABRIZIO 权利人:LUNDBECK PHARMACEUTICALS ITALY 摘要:A new process for the preparation and purification of 4-4′-diamino-diphenyl-sulfone (dapsone) is described. The process described is a three step process comprising a condensation reaction with the synthesis of a thioether intermediate and then steps of oxidation and reduction in suitable conditions in order to obtain a product with good yield and purity.
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-6562844-B2 优先权日:1998-01-23 标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-2008293970-A1 优先权日:2004-07-07 标 题:Process for Synthesis of 4-4'-Diamino-Diphenyl-Sulfone
专利号:WO-2006002690-A1 优先权日:2004-07-07 标 题 :Process for synthesis of 4-4'-diamino-diphenyl-sulfone
摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/S_schafer851.pdf