专利号:US-6858749-B2 优先权日:2000-02-04 标题:Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one 发明人:FLEMING MICHAEL P; HAN YEUN-KWEI; HODGES LEWIS M; JOHNSTON DAVID A; MICHELI ROGER P; PUENTENER KURT; ROBERTS CHRIS R; SCALONE MICHELANGELO; SCHWINDT MARK A; TOPPING ROBERT J 权利人:ROCHE COLORADO CORP 摘要:The present invention relates to a novel process for producing a delta-lactone of the formula:using an acyl halide of the formula:wherein R<1>, R<2 >R<3 >and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-delta-lactone.
专利号:US-6552204-B1 优先权日:2000-02-04 标 题 :Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one 发明人:HARRINGTON PETER J; HODGES LEWIS M; PUENTENER KURT; SCALONE MICHELANGELO 权利人:ROCHE COLORADO CORP 摘要:The present invention relates to a novel process for producing a δ-lactone of the formula: n using an acyl halide of the formula: n wherein R 1 , R 2 R 3 and X are described herein. In particular, the present invention relates to a process for enantioselectively producing the δ-lactone and novel intermediates disclosed herein.
专利号:US-2003158422-A1 优先权日:2000-02-04 标 题:Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
专利号:US-2003158423-A1 优先权日:2000-02-04 标 题:Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
专利号:US-5945559-A 优先权日:1996-05-24 标题:Process for producing 3-oxocarboxylic acid esters 发明人:SOTOGUCHI TSUKASA; YUASA YOSHIFUMI; TACHIKAWA AKIO; HARADA SHUNICHI 权利人:TAKASAGO PERFUMERY CO LTD 摘要:A novel process for producing 3-oxocarboxylic acid esters, which are useful as intermediates in the synthesis of ceramides to be used as a humectant, biodegradable polymers, drugs, etc., at a high purity and a high yield without requiring any troublesome procedure, is disclosed. The process comprises reacting an acetoacetic ester with a calcium compound, a barium compound or a strontium compound in the presence of an organic solvent at a temperature of 10 to 120 DEG C., further reacting the obtained product with a carboxylic acid chloride to thereby acylate it, and then adding thereto an alcohol in an amount 1 to 5 times by mol as much as the calcium compound, barium compound or strontium compound to thereby deacetylate the same.
专利号:JP-2009173635-A 优先权日:2000-02-04 标题:Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-2h-pyran-2-one