CAS: 887650-05-7; (S)-N-(3-([5,5'-Bipyrimidin]-2-Ylamino)-4-Methylphenyl)-4-((3-(Dimethylamino)Pyrrolidin-1-yl)Methyl)-3-(Trifluoromethyl)Benzamide

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4-(Bromomethyl)-3-Trifluoromethyl-N-{4-Methyl-3-[4-(5-Pyrimidinyl)Pyrimidin-2-Ylamino]Phenyl}Benzamide 859213-40-4

4-甲基-3-(三氟甲基)苯甲酸置于sodium Bromate,草酰氯,Potassium Carbonate,Sodium Hydrogensulfite,N,N-二甲基甲酰胺体系中,用 1,4-二氧六环,二氯甲烷,乙酸乙酯,N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 巴非替尼
参考文献:Design And Synthesis Of 3-Substituted Benzamide Derivatives As Bcr-Abl Kinase Inhibitors
标题:Design And Synthesis Of 3-Substituted Benzamide Derivatives As Bcr-Abl Kinase Inhibitors
摘要:A Series Of 3-Substituted Benzamide Derivatives Structurally Related To Sti-571 (Imatinib Mesylate),A Bcr-Abl Tyrosine Kinase Inhibitor Used To Treat Chronic Myeloid Leukemia (Cml),Was Prepared And Evaluated For Antiproliferative Activity Against The Bcr-Abl-Positive Leukemia Cell Line K562. About Ten 3-Halogenated And 3-Trifluoromethylated Benzamide Derivatives Were Identified As Highly Potent Bcr-Abl Kinase Inhibitors. One Of These,Ns-187 (9B),Is A Promising New Candidate Bcr-Abl Inhibitor For The Therapy Of Sti-571-Resistant Chronic Myeloid Leukemia. (C) 2005 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2005.11.042