CAS: 884330-09-0; 7'-Methyl-2'-Propyl-1H,3'H-2,5'-Bibenzo[d]Imidazole

该化合物是一种化学化合物,其结构由两个苯并米达罗装置组成,并有其他的烷基替代成分,可提高其特性;该化合物通常具有高度的熔点和良好的热稳定性,适合材料科学和有机合成的各种应用;其分子结构有助于其作为协调化学的悬浮体和作为制药或农用化学发展的一个构件的潜力;甲基和丙基基化合物的存在可以影响其溶解性和再活性,允许对其功能进行修改,使其适合特定用途;此外,这种化合物可能具有有趣的光学特性,可在电子或光学应用中加以利用;

英文名称7'-Methyl-2'-Propyl-1H,3'H-2,5'-Bibenzo[d]Imidazole
中文名称7'-甲基-2'-丙基-1H,3'H-2,5'-联苯并[d]咪唑
IUPAC名称7'-methyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
其它别名Telmisartan Dibenzimidazole N-Desmethyl 杂质; 6-(1H-Benzimidazol-2-yl)-4-Methyl-2-Propyl-1H-Benzimidazole
CAS编号884330-09-0
FDA UNII编号:Z3E2P8H433
分子式:C18H18N4分子量:290.37
产品CID: 1894862
产品分类有机原料→分子砌块→芳杂环类化合物→苯并咪唑类化合物

相似结构搜索
InChIKey: SJDKRRCPDBARHK-UHFFFAOYSA-N
InChI=1S/C18H18N4/c1-3-6-16-19-15-10-12(9-11(2)17(15)22-16)18-20-13-7-4-5-8-14(13)21-18/h4-5,7-10H,3,6H2,1-2H3,(H,19,22)(H,20,21)
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数3.0

相似化合物

152628-02-9 152628-02-9 99840-45-6

MSDS等安全信息

警示词warning
危险描述H303 +H313 +H333
防范说明P264+P280+P305+P351+P338+P337+P313
安全声明H303+H313+H333

上下游产品

CAS号95-54-5 邻苯二胺(OPD) | CAS号152628-03-0 2-正丙基-4-甲基-6-羧基苯并咪唑 | CAS号81684-80-2 1,2-Benzenediam... | CAS号152628-01-8 3-甲基-4-丁酰氨基-5-硝... | CAS号675882-71-0 3-甲基-4-丁酰氨基-5-氨...

合成工艺路线路线简述

📜3-甲基-4-丁酰氨基-5-硝基苯甲酸甲酯置于palladium On Activated Charcoal,氢气,Sodium Hydroxide体系中,用甲醇,水作为反应溶剂,25.0~155.0 °C,340.01 Kpa 条件下,反应 9.0H,反应生成 2-N-丙基-4-甲基-6-(1-苯并咪唑-2-基)苯并咪唑
参考文献:An Efficient And Impurity-Free Process For Telmisartan: An Antihypertensive Drug
标题:An Efficient And Impurity-Free Process For Telmisartan: An Antihypertensive Drug
摘要:Telmisartan (1),A Substituted Dibenzimidazole Derivative,Is An Antihypertensive Drug,Essentially Used To Control Blood Pressure. An Improved,Cost-Effective,And Impurity-Free Process For Telmisartan (1) Suitable For Large-Scale Production Is Described Here By Addressing Various Process Development Issues. The Overall Yield Obtained From This Newly Developed Process Is Around 50% (Over Five Steps) Compared To The Literature Reported Process (21%,Over Eight Steps).
DOI:10.1021/op060200G