CAS: 84-04-8; 1-[3-(2-Chlorophenothiazin-10-yl)Propyl]Piperidine-4-Carboxamide

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CAS号2765-59-5 2-氯-10-(3-氯丙基)吩噻嗪

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    专利号:US-2008214827-A1
    优先权日:2004-02-03
    标 题:Synthesis of Cyanoimino-Benzoimidazoles
    发明人:GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
    权利人:EURO CELTIQUE SA
    摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

    专利号:WO-0054773-A1
    优先权日:1999-03-12
    标题:Dopamine agonists in combination with nitric oxide donors, compositions and methods of use
    发明人:GARVEY DAVID S
    权利人:NITROMED INC; GARVEY DAVID S
    摘要:The present invention is directed to novel compositions comprising at least one dopamine agonist in combination with at least one nitric oxide donor (i.e. compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are substrates for nitric oxide synthase). The novel compositions may optionally comprise at least one therapeutic agent, such as, a vasoactive agent, an antimetic agent, and mixtures thereof. The dopamine agonist is preferably apomorphine. The present invention is also directed to methods for treating and/or preventing sexual dysfunctions and/or enhancing sexual responses in patients. In other embodiments, the present invention is directed to methods treating or preventing neurodegenerative diseases, mitochondrial diseases, spinal cord injury, central or psychostimulant addiction, senile dementia, circulatory disorders, cardiovascular disorders, hyperprolactinaemia or myopia. The compounds and/or compositions of the present invention can also be provided in the form of a pharmaceutical kit.

    专利号:EP-3103803-B1
    优先权日:2008-10-27
    标 题 :Intermediates for the synthesis of mtor kinase inhibitors

    专利号:CA-2555219-A1
    优先权日:2004-02-03
    标 题 :Synthesis of cyanoimino-benzoimidazoles

    专利号:US-11759496-B2
    优先权日:2016-05-10
    标题:Compounds and pharmaceutical use thereof in the treatment of cancer
    发明人:SUSIN SANTOS A; KAROYAN PHILIPPE; MERLE-BERAL HÉLÈNE
    权利人:KAROYAN PHILIPPE
    摘要:The present invention relates to a compound or a pharmaceutical salt thereof comprising a hexapeptide sequence of formula (I), its method of synthesis and its use in anticancer therapy. The invention also relates to a pharmaceutical composition for use in the treatment of cancer comprising at least one soluble peptide according to the invention or at least one acid nucleic according to the invention or at least one expression vector according to the invention, or at least one host cell according to the invention and a pharmaceutically acceptable carrier.

    专利号:WO-2005075459-A1
    优先权日:2004-02-03
    标题:Synthesis of cyanoimino-benzoimidazoles

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    1: TINA LU. Pipamazine, a new antiemetic. Clin Proc Child Hosp Dist Columbia. 1960 Sep;16:257-64.
    32:424-6. doi: 10.1093/bja/32.9.424.
    99:534-5. doi: 10.1001/archpedi.1960.02070030536017.
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