CAS: 812-01-1; Methylchlorosulfonate

该化合物是一种有机硫化合物,其特点是反应性和在有机合成中有用; 一种无色的黄色液体,其发光的气味和腐蚀性很强,具有高度腐蚀性和毒性; 化合物具有氯硫酸功能组,该组具有重要的反应性,特别是在核生殖替代反应中; 它在有机溶剂中可溶解,但与水发生强烈反应,释放盐酸和硫酸,这可能造成安全危害; 甲基氯硫酸主要用作各种有机化合物合成的试剂,包括制药和农用化学品; 由于腐蚀性,它需要谨慎地处理和储存适当的材料,以防止降解和确保安全; 此外,重要的是要注意,接触该化合物会导致严重的健康影响,因此在操作过程中必须使用个人防护设备.

结构式图片

相似化合物

49715-04-0

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

methanol methyl hyp°Chlorite dimethylsulfite methyl bisulfatemethylene chloride methyl bisulfate dimethyl sulfate methylamine

合成工艺路线路线简述

  • 合成目标产物 Methyl Chlorosulfonate 主要起始原料 Methanol
  • (文献来源)合成步骤主要原料 Methanol
📜氯甲酸甲酯置于氯磺酸体系中,化学反应生成 氯磺酸甲酯
参考文献:Kraft; Alexejew,Zhurnal Obshchei Khimii,1932,Vol. 2,P. 727
标题:Kraft; Alexejew,Zhurnal Obshchei Khimii,1932,Vol. 2,P. 727

海关参考信息

专利信息


专利号:US-4913852-A
优先权日:1986-06-24
标题 :Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with pregnane derivatives
发明人:MILIONI CATHERINE; EFTHYIMIOPOULOS CONSTANTIN; KOCH BERNARD; JUNG LOUIS; JUNG JEAN
权利人:MILIONI CATHERINE; EFTHYIMIOPOULOS CONSTANTIN; KOCH BERNARD; JUNG LOUIS; JUNG JEAN
摘要:Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with derivatives of Δ-4-pregnene-3,20-dione or with derivatives of Δ-1,4-pregnadiene-3,20-dione of the general formulas (I), (II) and (III), having glucocorticoidal and anti-inflammatory properties have been prepared and tested. Pharmaceutical compositions, medicaments containing them as well as their applications are claimed, particularly in the cutaneous and ophthalmic fields. ##STR1##

专利号:US-7429680-B2
优先权日:2004-02-17
标 题:Synthesis of sterically hindered secondary aminoether alcohols
发明人:SISKIN MICHAEL; KATRITZKY ALAN ROY; KIRICHENKO KOSTYANTYN MYKOLAYE
权利人:EXXONMOBIL RES & ENG CO
摘要:Severely sterically hindered secondary aminoether alcohols are prepared by reacting an organic carboxylic acid or alkali metal salt of an organic carboxylic acid with a sulfonyl halide, a sulfuryl halide, a mixed sulfuryl ester halide or a mixed sulfuryl amide halide to yield a sulfonic-carboxylic anhydride compound which is then reacted with a dioxane to cleave the ring of the dioxane, yielding a cleavage product which cleavage product is then aminated with an alkylamine and hydrolyzed with base to yield the severely sterically hindered secondary aminoether alcohol.

专利号:US-8853410-B2
优先权日:2009-04-30
标 题:Process for preparing substituted isoxazoline compounds and their precursors
发明人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN
权利人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN; BASF SE
摘要:The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) n nwhich are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I)n n nwherein R 1 to R 5 , R 8 and R 9 are described as in the description.n n The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.

专利号:US-2007219400-A1
优先权日:2004-02-17
标 题 :Synthesis of Sterically Hindered Secondary Aminoether Alcohols

专利号:US-4937379-A
优先权日:1986-08-01
标 题:Carboxylic acid synthesis process
发明人:GIORDANO CLAUDIO; VILLA MARCO
权利人:ZAMBON SPA
摘要:A process is described for preparing alpha-arylalkanoic acids, which comprises preparing and subsequently rearranging ketals of formula ##STR1## (in which Ar, R, R 1 , R 2 and R 4 have the meanings given in the description). n The ketals of formula II are prepared from the corresponding alpha-hydroxyketals. n The rearrangement reaction is conducted under mild conditions.

专利号:WO-2005081777-A2
优先权日:2004-02-17
标题:Synthesis of sterically hindered secondary aminoether alcohols

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✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Braverman, S.; Cherkinsky, M.; Birsa, M. L., Science of Synthesis, (2005) 18, 144.
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